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Effect of the Tubing Material Used in Peristaltic Pumping in Tangential Flow Filtration Processes of Biopharmaceutics on Particle Formation and Flux

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (3)

Tangential flow filtration (TFF) is a central step in manufacturing of biopharmaceutics. Membrane clogging leads to decreased permeate flux, longer pr......

Size Distribution Analysis of the Adeno-Associated Virus Vector by the c(s) Analysis of Band Sedimentation Analytical Ultracentrifugation with Multiwavelength Detection

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (4)

Adeno-associated virus (AAV) vector is a promising platform for in vivo gene therapy. The accurate assessment of distribution state of particles conta......

When Interactions Between Bile Salts and Cyclodextrin Cause a Negative Food Effect: Dynamic Dissolution/Permeation Studies with Itraconazole (Sporanox®) and Biomimetic Media

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (5)

The marketed oral solution of itraconazole (Sporanox (R)) contains 40% (259.2 mM) of 2-hydroxypropyl-b-cyclodextrin (HP -b-CD). The obvious role of HP......

Gelation Elimination and Crystallization Inhibition by Co-Amorphous Strategy for Amorphous Curcumin

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (1)

In the previous study, the development of amorphous curcumin (CUR) aimed to enhance the solubility/disso-lution of CUR by disrupting its crystal latti......

Rapid Insights into the Stabilization of Interferon Alpha by Two Surfactants Revealed by STD-NMR Spectroscopy

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (2)

Surfactants are commonly used in biopharmaceutical formulations to stabilize proteins against aggregation. However, the choice of a suitable surfactan......

Investigating the Correlation Between Drug Physical Properties and Physical Characteristics and Drug Entrapment Efficiencies of Chitosan-TPP Nanoparticles

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (12)

Chitosan nanoparticles (NPs) have been the subject of intensive research. This study aimed to determine how different drug characteristics such as mol......

Preparation and Evaluation of Hydrogel Film Containing Tramadol for Reduction of Peripheral Neuropathic Pain

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (1)

To develop and assess new dosage forms for the alternative to existing oral medication for peripheral neu-ropathy, a hydrogel film in the skin patch f......

Functional Characterization of Extracellular Vesicles from Baker's Yeast Saccharomyces Cerevisiae as a Novel Vaccine Material for Immune Cell Maturation

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (2)

Extracellular vesicles (EVs) encapsulate various bioactive molecules, and much effort has been directed towards developing a novel EV-based therapy. A......

Intravaginal Drug Delivery Systems to Treat the Genitourinary Syndrome of Menopause: Towards the Design of Safe and Efficacious Estrogen-loaded Prototypes

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (6)

Estrogens locally delivered to the vagina by tablets, capsules, rings, pessaries, and creams are the most com-mon and highly recommended platforms to ......

Heat-Triggered Release of Dexamethasone from Thermosensitive Liposomes Using Prodrugs or Excipients

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (7)

Dexamethasone (DXM) is a potent glucocorticoid with an anti-inflammatory and anti-angiogenic activity which is widely clinically used. Systemic side e......

How can Electrospinning Further Service Well for Pharmaceutical Researches?

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (11)

The past two decades have witnessed the enormous success and progress of electrospinning, as well as its broad and useful applications in pharmaceutic......

Solid Forms of The New Antitrypanosomal 1-(4-Acetamide-Benzenesulfonyl)-Benzimidazole: Preparation and Physicochemical Characterization

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (12)

This study aimed to investigate the polymorphism of 1-(4-acetamide-benzenesulfonyl)-benzimidazole (PABZI), a newly developed compound with significant......

Coupled Diffusion-Binding-Deformation Modelling for Phase-Transition Microneedles-Based Drug Delivery

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (4)

Phase-transition microneedles (PTMNs)-based transdermal drug delivery (TDD) is gaining popularity due to its non-invasiveness and ability to deliver a......

Assessment of Epithelial Lining Fluid Partitioning of Systemically Administered Monoclonal Antibodies in Rats

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (4)

For systemically administered monoclonal antibodies (mAbs) with pharmacological targets in the epithelial lining fluid (ELF), information on the parti......

Quercetin Loaded Silica and Gold-Coated Silica Nanoparticles: Characterization, Evaluation and Comparison of Their in vitro Characteristics

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 112 (6)

Herein, silica nanoparticles (NPs) and gold-silica NPs were loaded with the anti-cancer agent quercetin (QC) to produce silica NPs-QC and gold coated ......

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