期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; 50 (5)
Global sensitivity analysis (GSA) evaluates the impact of variability and/or uncertainty of the model parameters on given model outputs. GSA is useful......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; ()
Clinical studies have found there still exists a lack of gene therapy dose-toxicity and dose-efficacy data that causes gene therapy dose selection to ......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; 50 (5)
Simulations from population models have critical applications in drug discovery and development. Avatars or digital twins, defined as individual simul......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; ()
Machine Learning (ML) is a fast-evolving field, integrated in many of today's scientific disciplines. With the recent development of neural ordinary d......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; 50 (2)
This study presents a new two compartmental model with, recently defined General fractional derivative. We review that concept of General fractional d......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; ()
Mathematical modelling has become a key tool in pharmacological analysis, towards understanding dynamics of cell signalling and quantifying ligand-rec......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; ()
Biological therapies may act as immunogenic triggers leading to the formation of anti-drug antibodies (ADAs). Population pharmacokinetic (PK) models c......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; 50 (1)
Colistin remains one of the few available options for the treatment of infections caused by resistant bacteria. Pharmacokinetic (PK) studies have been......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; ()
Covariate identification is an important step in the development of a population pharmacokinetic/pharmacodynamic model. Among the different available ......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; ()
Physiologically based pharmacokinetic (PBPK) models can be used to leverage physiological and in vitro data to predict monoclonal antibody (mAb) conce......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; 50 (4)
Methylphenidate (MPH) is a psychostimulant which inhibits the uptake of dopamine and norepinephrine transporters, DAT and NET, and is mostly used to t......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; 50 (6)
Dose selection is an integral part of a molecule's journey to become medicine. On top of typical challenges faced in dose selection for more common di......
期刊： JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2023; ()
The use of beta-lactam (BL) and beta-lactamase inhibitor (BLI) combinations, such as piperacillin-tazobactam (PIP-TAZ) is an effective strategy to com......
