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Sacubitril/valsartan cardioprotective effect against cisplatin-induced cardiotoxicity via modulation of VEGF/eNOS and TLR4/TNFα/IL6 signalling pathways

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (9)

Objectives Drug-induced cardiac injury is a potentially preventable cause of heart failure. Cisplatin (CIS) is a widely used chemotherapeutic agent co......

Pharmacological properties and derivatives of saikosaponins-a review of recent studies

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (7)

Objectives Saikosaponins (SSs) constitute a class of medicinal monomers characterised by a triterpene tricyclic structure. Despite their potential the......

Mitochondrial transplantation attenuates toxicity in rat renal proximal tubular cells caused by Favipiravir

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (11)

Objectives Exogenous mitochondria transplantation or mitotherapy can be used to swap out unhealthy mitochondria for functioning ones. Treatment of mit......

N(Omega)-nitro-l-arginine methyl ester potentiates lidocaine analgesic and anaesthetic effect in rats

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (1)

Objectives The purpose of the experiment was to study the effect of L-NAME (N(Omega)-nitro-L-arginine methyl ester) and its cotreatment with lidocaine......

A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Shen-Kui-Tong-Mai granules on a rat model with chronic heart failure

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (6)

Objectives This study aimed to comprehensively investigate the potential active components and therapeutic mechanisms of Shen-Kui-Tong-Mai granule (SK......

Investigation of the effect of concurrently administered carvedilol, atorvastatin and bile salts on intestinal absorption of linagliptin

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; ()

Objectives The aim of this work was to investigate the regional difference in linagliptin intestinal membrane transport and to investigate the effects......

Evaluation of in vivo and ex vivo pre-treated bone marrow-derived mesenchymal stem cells with resveratrol in streptozotocin-induced type 1 diabetic rats

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (9)

Objectives To compare the therapeutic potential of rat bone marrow-derived mesenchymal stem cells (BM-MSCs) preconditioned ex-vivo with resveratrol (M......

Icariside I reduces breast cancer proliferation, apoptosis, invasion, and metastasis probably through inhibiting IL-6/STAT3 signaling pathway

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; ()

Objectives Breast cancer is a common malignancy in women. More than 90% of breast cancer deaths are caused by metastasis. Epimedii Folium (EF) is a co......

Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α signaling pathway

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (12)

Objectives: To explore the effect of extract of Styrax (ES) on myocardial ischemic injury and its molecular mechanism, indirectly providing a theoreti......

Fulvestrant alleviates cisplatin-induced acute kidney injury via repression of BNIP3-mediated apoptosis and autophagy

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; ()

Cisplatin-induced acute kidney injury (AKI) is a clinical disease characterized by a sudden loss of renal function within a few hours or days, due to ......

A comprehensive review of phytochemistry, pharmacology and quality control of plants from the genus Viola

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (1)

Objectives The genus Viola belongs to the family Violaceae, and the plants from this genus are essential folk herb medicine extensively used in many a......

Circ_0000253 promotes the progression of osteosarcoma via the miR-1236-3p/SP1 axis

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (2)

Objective Circular RNAs (circRNAs) play important roles in modulating tumour progression. This study investigated the role of circ_0000253 in osteosar......

Flavonoids as new regulators of mitochondrial potassium channels: contribution to cardioprotection

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (4)

Objectives Acute myocardial ischemia is one of the major causes of illness in western society. Reduced coronary blood supply leads to cell death and l......

Study of the inclusion complexes formed between 4-phenylbutyrate and α-, β- and γ-cyclodextrin in solution and evaluation on their taste-masking properties

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; 75 (2)

Objectives 4-Phenylbutyrate (PB), which is used in the management of urea cycle disorders, has an unpleasant taste leading to poor patient compliance.......

Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2023; ()

Objectives Cyclophosphamide is a chemotherapeutic agent and immunosuppressant drug; however, it damages the liver. This study investigates the protect......

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