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Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (1)

It has been reported that stressful events in early life influence behavior in adulthood and are associated with different psychiatric disorders, such......

Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (3)

Kidney ischemia/reper fusion (I/R) injury, a common cause of acute kidney injury (AKI), is associated with the migration of inflammatory cells into th......

Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen species-dependent inactivation of the PI3K/AKT pathway

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (4)

Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral species Cladiella australis, ......

Network pharmacology and molecular docking reveal the mechanism of Qinghua Xiaoyong Formula in Crohn's disease

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (4)

Crohn's disease (CD) is a chronic inflammatory illness of the digestive system with unknown etiology, and its incidence is increasing worldwide. Howev......

Involvement of α1β-adrenoceptors and Rho kinase in contractions of rat aorta and mouse spleen

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (4)

alpha 1-adrenoceptors link via the G-protein Gq/G(11) to both Ca2+ entry and release from stores, but may also activate Rho kinase, which causes calci......

Hydrogen sulfide alleviates hypothyroidism-induced myocardial fibrosis in rats through stimulating autophagy and inhibiting TGF-(31/Smad2 pathway

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (1)

Hypothyroidism alone can lead to myocardial fibrosis and result in heart failure, but traditional hormone replacement therapy does not improve the fib......

Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (2)

Transient receptor potential canonical (TRPC) channels are non-selective calcium-permeable cation channels. It is suggested that TRPC4(3 is regulated ......

Encainide, a class Ic anti-arrhythmic agent, blocks voltage-dependent potassium channels in coronary artery smooth muscle cells

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (4)

Voltage- dependent K+ (Kv) channels are widely expressed on vascular smooth muscle cells and regulate vascular tone. Here, we explored the inhibitory ......

Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (3)

This study is to determine the regulation of nitric oxide synthase 3 (NOS3) by edaravone in mice with hypoxic pulmonary hypertension (HPH). C57BL/6J m......

LINC00562 drives gastric cancer development by regulating miR-4636-AP1S3 axis

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (3)

Dysregulation of certain long non-coding RNAs may facilitate tumor initiation and progression. However, numerous carcinogenesis-related long non -codi......

Mad2B forms a complex with Cdc20, Cdc27, Rev3 and Rev1 in response to cisplatin-induced DNA damage

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (5)

Mitotic arrest deficient 2 like 2 (Mad2L2, also known as Mad2B), the human homologue of the yeast Rev7 protein, is a regulatory subunit of DNA poly-me......

Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (5)

Diabetic ulcer is usually seen in people with uncontrolled blood sugar. Reportedly, many factors such as impaired glucose metabolism, and macrovascula......

Effects of rosiglitazone, an antidiabetic drug, on Kv3.1 channels

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (1)

Rosiglitazone is a thiazolidinedione-class antidiabetic drug that reduces blood glucose and glycated hemoglobin levels. We here investigated the inter......

Lyso-globotriaosylsphingosine induces endothelial dysfunction via autophagy-dependent regulation of necroptosis

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2023; 27 (3)

Fabry disease is a lysosomal storage disorder characterized by the lyso-somal accumulations of glycosphingolipids in a variety of cytotypes, which inc......

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