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Cysteine-rich domain of type III collagen N-propeptide inhibits fibroblast activation by attenuating TGFI3 signaling

期刊: MATRIX BIOLOGY, 2022; 109 ()

TGF3 is a key regulator of the dynamic reciprocity between cells and the extracellular matrix that drives physiologic and pathologic responses in both......

JIF:11.276

Infiltrating CD8+T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers

期刊: MATRIX BIOLOGY, 2023; 116 ()

Tracks rich in matrix and cells, as described in several cancer types, have immunosuppressive functions and separate tumor nests and stroma, yet their......

Mutant MESD links cellular stress to type I collagen aggregation in osteogenesis imperfecta type XX

期刊: MATRIX BIOLOGY, 2023; 115 ()

Aberrant forms of endoplasmic reticulum (ER)-resident chaperones are implicated in loss of protein quality control in rare diseases. Here we report a ......

Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney

期刊: MATRIX BIOLOGY, 2023; 121 ()

During ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histo......

The extracellular matrix-immune microenvironment crosstalk in cancer therapy: Challenges and opportunities

期刊: MATRIX BIOLOGY, 2023; 121 ()

Targeting the tumour immune microenvironment (TIME) by cancer immunotherapy has led to improved patient outcomes. However, response to these treatment......

Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons

期刊: MATRIX BIOLOGY, 2023; 115 ()

The specific viscoelastic mechanical properties of Achilles tendons are highly dependent on the structural characteristics of collagen at and between ......

Dual role of enhancer of zeste homolog 2 in the regulation of ultraviolet radiation-induced matrix metalloproteinase-1 and type I procollagen expression in human dermal fibroblasts

期刊: MATRIX BIOLOGY, 2023; 119 ()

Abnormalities in the extracellular matrix (ECM) caused by ultraviolet (UV) radiation are mediated by epige-netic mechanisms. Enhancer of zeste homolog......

Tissue-specific collagen hydroxylation at GEP/GDP triplets mediated by P4HA2

期刊: MATRIX BIOLOGY, 2023; 119 ()

Collagen, the most abundant organic compound of vertebrate organisms, is a supramolecular, protein-made polymer. Details of its post-translational mat......

Endothelial basement membrane laminins- new players in mouse and human myoendothelial junctions and shear stress communication

期刊: MATRIX BIOLOGY, 2023; 121 ()

Basement membranes (BMs) are critical but frequently ignored components of the vascular system. Using high-resolution confocal imaging of whole-mount-......

Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro

期刊: MATRIX BIOLOGY, 2023; 115 ()

Transplantation of islets of Langerhans is a promising alternative treatment strategy in severe cases of type 1 diabetes mellitus; however, the succes......

Tumor-associated fibrosis impairs the response to immunotherapy

期刊: MATRIX BIOLOGY, 2023; 119 ()

Previously, impaired responses to immunotherapy in cancer had been attributed mainly to inherent tumor characteristics (tumor cell intrinsic factors) ......

Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure

期刊: MATRIX BIOLOGY, 2023; 121 ()

Osteogenesis imperfecta (OI) is a family of rare heritable skeletal disorders associated with dominant muta-tions in the collagen type I encoding gene......

Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology

期刊: MATRIX BIOLOGY, 2023; 118 ()

High-grade serous ovarian cancer (HGSOC) is notoriously known as the silent killer of post-menopausal women as it has an insidious progression and is ......

ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation

期刊: MATRIX BIOLOGY, 2023; 121 ()

Proteases have long been associated with cancer progression, due to their ability to facilitate invasion upon matrix remodelling. However, proteases a......

Controlled extracellular proteolysis of thrombospondins

期刊: MATRIX BIOLOGY, 2023; 119 ()

Limited proteolysis of thrombospondins is a powerful mechanism to ensure dynamic tuning of their activities in the extracellular space. Thrombospondin......

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