期刊: MATRIX BIOLOGY, 2022; 109 ()
TGF3 is a key regulator of the dynamic reciprocity between cells and the extracellular matrix that drives physiologic and pathologic responses in both......
期刊: MATRIX BIOLOGY, 2023; 116 ()
Tracks rich in matrix and cells, as described in several cancer types, have immunosuppressive functions and separate tumor nests and stroma, yet their......
期刊: MATRIX BIOLOGY, 2023; 115 ()
Aberrant forms of endoplasmic reticulum (ER)-resident chaperones are implicated in loss of protein quality control in rare diseases. Here we report a ......
期刊: MATRIX BIOLOGY, 2023; 121 ()
During ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histo......
期刊: MATRIX BIOLOGY, 2023; 121 ()
Targeting the tumour immune microenvironment (TIME) by cancer immunotherapy has led to improved patient outcomes. However, response to these treatment......
期刊: MATRIX BIOLOGY, 2023; 115 ()
The specific viscoelastic mechanical properties of Achilles tendons are highly dependent on the structural characteristics of collagen at and between ......
期刊: MATRIX BIOLOGY, 2023; 119 ()
Abnormalities in the extracellular matrix (ECM) caused by ultraviolet (UV) radiation are mediated by epige-netic mechanisms. Enhancer of zeste homolog......
期刊: MATRIX BIOLOGY, 2023; 119 ()
Collagen, the most abundant organic compound of vertebrate organisms, is a supramolecular, protein-made polymer. Details of its post-translational mat......
期刊: MATRIX BIOLOGY, 2023; 121 ()
Basement membranes (BMs) are critical but frequently ignored components of the vascular system. Using high-resolution confocal imaging of whole-mount-......
期刊: MATRIX BIOLOGY, 2023; 115 ()
Transplantation of islets of Langerhans is a promising alternative treatment strategy in severe cases of type 1 diabetes mellitus; however, the succes......
期刊: MATRIX BIOLOGY, 2023; 119 ()
Previously, impaired responses to immunotherapy in cancer had been attributed mainly to inherent tumor characteristics (tumor cell intrinsic factors) ......
期刊: MATRIX BIOLOGY, 2023; 121 ()
Osteogenesis imperfecta (OI) is a family of rare heritable skeletal disorders associated with dominant muta-tions in the collagen type I encoding gene......
期刊: MATRIX BIOLOGY, 2023; 118 ()
High-grade serous ovarian cancer (HGSOC) is notoriously known as the silent killer of post-menopausal women as it has an insidious progression and is ......
期刊: MATRIX BIOLOGY, 2023; 121 ()
Proteases have long been associated with cancer progression, due to their ability to facilitate invasion upon matrix remodelling. However, proteases a......
期刊: MATRIX BIOLOGY, 2023; 119 ()
Limited proteolysis of thrombospondins is a powerful mechanism to ensure dynamic tuning of their activities in the extracellular space. Thrombospondin......