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Histone deacetylase inhibitor 2-hexyl-4-pentynoic acid enhances hydroxyurea therapeutic effect in triple-negative breast cancer cells

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 873 ()

Triple-negative breast cancer (TNBC) treatment has only limited effect, and it causes a significant number of deaths. Histone deacetylase inhibitors (......

JIF:2.665

Genomic instability evaluation by BMCyt and telomere length in Brazilian family farmers exposed to pesticides

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 878 ()

Brazil is one of the largest consumers of pesticides in the world. This high consumption has resulted in higher potential health risk to agricultural ......

JIF:2.665

Effects of antioxidant capacity on micronucleus induction by cigarette smoke in mammalian cells

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 873 ()

We have compared micronucleus (MN) induction by cigarette smoke in the L5178Y, TK6, and CHL/IU cell lines. The test sample was total particulate matte......

JIF:2.665

Epigenetic effects of graphene oxide and its derivatives: A mini-review

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 878 ()

ABSTR A C T Graphene oxide (GO), an engineered nanomaterial, has a two-dimensional structure with carbon atoms arranged in a hexagonal array. While it......

JIF:2.665

Role of Xeroderma pigmentosum D (XPD) protein in genome maintenance in human cells under oxidative stress

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 876 ()

Xeroderma pigmentosum D (XPD) protein plays a pivotal role in the nucleotide excision repair pathway. XPD unwinds the local area of the damaged DNA by......

JIF:2.665

Dose response to methylating agents in the gamma H2AX, SCE and colony formation assays: Effect of MGMT and MPG overexpression

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 876 ()

Cells have developed diverse protective mechanisms that enable them to tolerate low doses of genotoxic compounds. DNA repair processes attenuate the m......

JIF:2.665

Potent mutagenicity of an azide, 3-azido-1,2-propanediol, in human TK6 cells

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 876 ()

Sodium azide is a strong mutagen that has been successfully employed in mutation breeding of crop plants. In biological systems, it is metabolically c......

JIF:2.665

Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 876 ()

Aging-related impaired body structure and functions may be, at least partially, caused by elevated oxidative stress. Melatonin (MEL) and resveratrol (......

JIF:2.665

Buccal micronucleus cytome assay in children living in an area with low anthropogenic pressure: The EFFE.BIP study

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 873 ()

The study aimed to evaluate the micronucleus (MN) frequency in exfoliated buccal cells (EBCs) of 256 6-8-yearsold schoolchildren living in a rural are......

JIF:2.665

Alternariol monomethyl ether toxicity and genotoxicity in male Sprague-Dawley rats: 28-Day in vivo multi-endpoint assessment

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 873 ()

Alternariol monomethyl ether (AME), a typical Alternaria toxin, has often been detected in grains. We have measured the general toxicity and genotoxic......

JIF:2.665

Exposure in the tobacco fields: Genetic damage and oxidative stress in tobacco farmers occupationally exposed during harvest and grading seasons

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 878 ()

Agricultural workers engaged in tobacco cultivation are constantly exposed to large amounts of harmful agents, such as pesticides and nicotine. Furthe......

JIF:2.665

DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide

期刊: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022; 878 ()

Human DNA polymerases can bypass DNA lesions performing translesion synthesis (TLS), a mechanism of DNA damage tolerance. Tumor cells use this mechani......

JIF:2.665

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