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Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; 30 (1)

The endosomal sorting complex required for transport (ESCRT) is a highly conserved protein machinery that drives a divers set of physiological and pat......

Endogenous retroviruses control human placental gene expression

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; 30 (4)

Endogenous retroviruses (ERVs), a type of transposable element (TE), have been incorporated throughout evolution into the human genome. We show that m......

Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; 30 (5)

Transcriptional bursting has been linked to the stochastic positioning of nucleosomes. However, how bursting is regulated by the remodeling of promote......

Quantifying how promoter-associated nucleosomes regulate transcriptional bursting

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; 30 (5)

Single-molecule live-cell imaging of the transcription dynamics in budding yeast cells revealed that the remodeling of different nucleosomes in the pr......

Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; ()

In mammals, the kidney plays an essential role in maintaining blood homeostasis through the selective uptake, retention or elimination of toxins, drug......

Pioneers conquer core histones at the chromatin frontier

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; ()

Pioneer transcription factors access gene regulatory sites embedded within chromatin. They drive gene expression programs vital for cell fate decision......

The Mediator complex regulates long-range communication in the genome

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; 30 (7)

The activity of genes is controlled by regulatory DNA sequences, which interact and communicate with their target genes over long genomic distances. N......

RNA polymerase II pausing regulates chromatin organization in erythrocytes

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; ()

Here, the authors show that although transcription is severely diminished in nucleated erythrocytes, it persists at genes involved in promoter-proxima......

Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; 30 (9)

Translation affects messenger RNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mamm......

Our 30th anniversary is approaching. We want to hear from you

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; 30 (9)

In January 2024, Nature Structural & Molecular Biology (NSMB) will celebrate the 30th anniversary of publishing its first issue. Though initially ......

Transient protein folding in condensates reveals ways to target disordered oncoproteins

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; ()

The androgen receptor forms nuclear condensates associated with gene transcription. Investigating the molecular basis of condensate formation led us t......

Structural basis of metabolite transport by the chloroplast outer envelope channel OEP21

期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023; 30 (6)

Triose phosphates (TPs) are the primary products of photosynthetic CO2 fixation in chloroplasts, which need to be exported into the cytosol across the......

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