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The roles of extracellular vesicles in the immune system

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (4)

The twenty-first century has witnessed major developments in the field of extracellular vesicle (EV) research, including significant steps towards def......

Perforin 2 mediates endosomal antigen export for cross-presentation

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (6)

A preprint by Rodriguez-Silvestre et al. describes a mechanism for the export of antigens from endosomes regulated by perforin 2, for cross-presentati......

Pancreatitis points to key role of dendritic cells in pancreatic cancer

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (6)

A preprint by Mahadevan et al. shows that pancreatitis alters the immune landscape of mice with pancreatic ductal adenocarcinoma and highlights a role......

Daughters forget, mothers remember

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (11)

Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and protects against future preg......

Olfactory immunology: the missing piece in airway and CNS defence

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; ()

The olfactory mucosa is a component of the nasal airway that mediates the sense of smell. Recent studies point to an important role for the olfactory ......

Tuning immunity through tissue mechanotransduction

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (3)

Immune responses are governed by signals from the tissue microenvironment, and in addition to biochemical signals, mechanical cues and forces arising ......

COVID-19 and cellular senescence

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (4)

The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host factors. Recent advances point to cellular senescence, an a......

Reclassifying plasmacytoid dendritic cells as innate lymphocytes Comment

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (1)

With respect to their ontogeny, emerging data support a lymphoid origin of plasmacytoid dendritic cells (pDCs), which seem to share a developmental tr......

TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (6)

In this Review, the authors consider the many diverse ways in which the cytokine transforming growth factor-beta (TGF beta) can regulate immune respon......

Therapeutic induction of antigen-specific immune tolerance

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; ()

The development of therapeutic approaches for the induction of robust, long-lasting and antigen-specific immune tolerance remains an important unmet c......

Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

期刊: NATURE REVIEWS IMMUNOLOGY, 2023; 23 (3)

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specif......

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