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Myxoid glioneuronal tumor: Histopathologic, neuroradiologic, and molecular features in a single center series

期刊: NEOPLASIA, 2023; 37 ()

Background: Myxoid glioneuronal tumor (MGT) is a benign glioneuronal neoplasm recently introduced in the World Health Organization (WHO) classificatio......

P110a inhibitor alpelisib exhibits a synergistic effect with pyrotinib and reverses pyrotinib resistant in HER2+breast cancer

期刊: NEOPLASIA, 2023; 43 ()

Human epidermal growth factor receptor 2 (HER2) plays a critical role in breast cancer progression in patients with HER2 overexpression, thereby drivi......

Altered endosomal-lysosomal biogenesis in melanoma

期刊: NEOPLASIA, 2023; 43 ()

Cutaneous melanoma is the deadliest form of skin neoplasm and its high mortality rates could be averted by early accurate detection. While the detecti......

Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells

期刊: NEOPLASIA, 2023; 45 ()

Purpose: Human papilloma virus (HPV) positive head and neck squamous cell carcinoma (HNSCC) tumors respond significantly better to anticancer treatmen......

Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling

期刊: NEOPLASIA, 2023; 36 ()

Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive and lethal malignancies world-wide with an urgent need for new diagnosti......

Slow-cycling murine melanoma cells display plasticity and enhanced tumorigenicity in syngeneic transplantation assay

期刊: NEOPLASIA, 2023; 36 ()

Slow-cycling cancer cells (SCC) contribute to the aggressiveness of many cancers, and their invasiveness and chemoresistance pose a great therapeutic ......

Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy

期刊: NEOPLASIA, 2023; 46 ()

Triple negative breast cancer (TNBC) is an aggressive malignancy for which chemotherapy remains the standard treatment. However, between 3 and 5 years......

Targeting Na-H exchanger 1 overcomes nuclear factor kappa B-mediated tumor resistance to radiotherapy

期刊: NEOPLASIA, 2023; 35 ()

Intrinsic or acquired radioresistance often limits the efficacy of radiation therapy (RT), thereby leading to local control failure. Cancerous cells h......

Proteomic profiling of canine fibrosarcoma and adjacent peritumoral tissue

期刊: NEOPLASIA, 2023; 35 ()

Fibrosarcoma (FSA) are rare soft tissue tumors that display aggressive local behavior and invasive growth leading to high rates of tumor recurrence. W......

Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells

期刊: NEOPLASIA, 2023; 41 ()

Nicotinamide phosphoribosyltransferase (NAMPT) is a key metabolic enzyme in NAD + synthesis pathways and is found upregulated in several tumors, depic......

Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice

期刊: NEOPLASIA, 2023; 45 ()

The homeostasis of the gut microbiota and circadian rhythm is critical to host health, and both are inextricably intertwined with lung cancer. Althoug......

Innate immunity: Looking beyond T-cells in radiation and immunotherapy combinations

期刊: NEOPLASIA, 2023; 46 ()

Radiation therapy is an established and effective anti-cancer treatment modality. Extensive pre-clinical experimentation has demonstrated that the pro......

Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer

期刊: NEOPLASIA, 2023; 35 ()

Fusobacterium nucleatum ( F. nucleatum) is enriched in colorectal cancer (CRC) tissues and a high amount of F. nucleatum was associated with an immuno......

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