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Topical foam as a promising carrier system for active pharmaceutical ingredients: review of clinical studies

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (8)

Skin disorders are preferentially treated by topical administration of medicines or cosmetics because of the possibility of local action. However, a g......

Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (8)

The study developed and evaluated Sorafenib Tosylate (SRT)-loaded polymeric microparticles (MPs) using biodegradable polymer polycaprolactone (PCL) as......

Transethosome as a versatile nano vehicle for various indications and its regulatory insights

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (10)

Transethosomes, classified as 3rd generation nanocarriers, have gained global acclaim due to their profound potential in addressing diverse medical co......

Incorporation of exemestane into ternary nanosponge system for enhanced anti-tumor potential in breast cancer

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (10)

The present investigation reports the potential of exemestane loaded cyclodextrin based nanosponges for the treatment of breast cancer. Fourier transf......

Effervescence-induced amorphous solid dispersions with improved drug solubility and dissolution

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (2)

The current study aimed to investigate drug carrier miscibility in pharmaceutical solid dispersions (SD) and include the effervescent system, i.e. Eff......

Chitosan functionalized PCL nanoparticles bearing tyrosine kinase inhibitor osimertinib mesylate for effective lung cancer therapy

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (5)

Lung cancer ranks second position among the cancer-related deaths. Osimertinib mesylate (OSM) is a tyrosine-kinase-inhibitor which can effectively tre......

Optimization of topical curcumin spanlastics for melanoma treatment

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (5)

The aim of the study was to enhance curcumin skin permeability through the preparation of spanlastics. Spanlastics were prepared using the ethanol inj......

Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs: polymer materials and solvent casting micromoulding method

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (10)

Proteins and peptides are rapidly developing pharmaceutical products and are expected to continue growing in the future. However, due to their nature,......

Surface Modification of lactose carrier particles using a fluid bed coater to improve fine particle fraction for dry powder inhalers

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (2)

Surface roughness of carrier particles can impact dry powder inhaler (DPI) performance. There are opposing views on the effect of roughness on DPI per......

Investigations into the use of machine learning to predict drug dosage form design to obtain desired release profiles for 3D printed oral medicines

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (2)

Three-dimensional (3D) printing, digitalization, and artificial intelligence (AI) are gaining increasing interest in modern medicine. All three aspect......

Characterization of co-amorphous carvedilol-maleic acid system prepared by solvent evaporation

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (3-4)

The aim of this study was to enhance the solubility and stability of the water-insoluble drug carvedilol (CAR) with maleic acid (MLE) to create a co-a......

Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (3-4)

Enalapril (EN) is an antihypertensive drug that is sparingly soluble in water with limited oral bioavailability. Successfully prepared self-nanoemulsi......

Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (5)

This study aimed to improve the use of YF8, a matrine derivative obtained through chemical transformation of matrine extracted from Sophora alopecuroi......

Microemulsion-thermosensitive gel composites as in situ-forming drug reservoir for periodontitis tissue repair through alveolar bone and collagen regeneration strategy

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (1)

A satisfactory clinical effect in treating periodontitis is often difficult to achieve by conventional non-surgical systemic drug delivery due to the ......

Sodium hyaluronate dry powder inhalation in combination with sodium cromoglycate prepared using optimized spray drying conditions

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2023; 28 (2)

Sodium hyaluronate (SHA) is an anti-inflammatory and protective agent against bronchoconstriction, and sodium cromoglicate (SCG) prevents exercise-ind......

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