期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (6)
Despite the fact that roughly 40% of all US Food and Drug Administration (FDA)-approved pharmacological therapeutics target G protein- coupled recepto......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (4)
Personalized medicine tailors therapies, disease prevention, and health maintenance to the indi-vidual, with pharmacogenomics serving as a key tool to......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (2)
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in the United States and many other countries. DKD occurs through......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (4)
Parkinson's disease (PD) is a neurode-generative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compact......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (2)
Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100 years. This anticoagulant activity is attributed mainly to t......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (1)
Janus kinase (JAK) sig-naling is an appreciated drug target in human cancers. Numerous mutant JAK molecules as well as inherent and acquired drug resi......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (6)
agents used to treat or manage diseases can modify the level of heat strain ex-perienced by chronically ill and elderly patients via dif-ferent mechan......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (4)
Over the past few decades, humankind has constantly encountered new viral species that cre-ate havoc in the socioeconomic balance worldwide. Among the......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (3)
The development of cutting-edge tech-niques to study specific brain regions and neural cir-cuits that regulate sleep-wake brain states and general ane......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (3)
G protein-coupled receptors (GPCRs) are key drug targets due to their involvement in many physio-logical processes. The complexity of receptor pharmac......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (5)
The endoplasmic reticulum (ER) is the largest organelle of the cell, composed of a continuous network of sheets and tubules, and is involved in protei......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (6)
Chronic lung rejection, also called chronic lung allograft dysfunction (CLAD), remains the major hurdle limiting long-term survival after lung transpl......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (1)
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cogn......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (5)
1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water flow into the canalicular conduit is in response to an osmotic......
期刊： PHARMACOLOGICAL REVIEWS, 2023; 75 (6)
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is activated by ligand binding, overexpression, or mutation. It is well known for......
