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Semaphorin 4D Promotes Osteoclast Formation but Inhibits Osteoblast Formation: Implication in Bisphosphonate-Related Osteonecrosis of the Jaw

期刊: PHARMACOLOGY, 2023; 108 (4)

Introduction: Bisphosphonates are widely used for the treatment of osteoporosis, which could cause osteonecrosis of the jaw (also known as bisphosphon......

What Women Want? The State of the Art regarding the Treatment of Young Women with Hypoactive Sexual Desire Disorder

期刊: PHARMACOLOGY, 2023; ()

Background: Hypoactive sexual desire disorder (HSDD) in premenopausal women involves biological, psychological, and social aspects. In the European So......

Regulation of the Endogenous Opiate Signaling Pathway against Oxidative Stress and Inflammation: A Considerable Approach for Exploring Preclinical Treatment of Parkinson's Disease

期刊: PHARMACOLOGY, 2023; 108 (6)

Introduction: Oxidative stress and inflammation are major factors contributing to the progressive death of dopaminergic neurons in Parkinson's disease......

Alkaloids in Withania somnifera (L.) Dunal Root Extract Contribute to Its Anti-Inflammatory Activity

期刊: PHARMACOLOGY, 2023; 108 (3)

The anti-inflammatory properties of the medicinal plant Withania somnifera (L.) Dunal (WS) are generally related to withanolides; consistently, severa......

Factors Associated with Potentially Inappropriate Prescribing in Patients on Peritoneal Dialysis

期刊: PHARMACOLOGY, 2023; 108 (1)

Introduction: Inappropriate prescribing is common in patients with end-stage kidney disease, especially in those over 65 years of age. Our study aimed......

The Aryl Hydrocarbon Receptor Ligand 6-Formylindolo(3,2-b)carbazole Promotes Estrogen Receptor Alpha and c-Fos Protein Degradation and Inhibits MCF-7 Cell Proliferation and Migration

期刊: PHARMACOLOGY, 2023; 108 (2)

Introduction: Worldwide, breast cancer is the most common cancer in women and is the main cause of death among all neoplasia in this group. Luminal A ......

Cardiometabolic Risk Factors in Atorvastatin-Treated Women with Euthyroid Autoimmune Thyroiditis

期刊: PHARMACOLOGY, 2023; 108 (3)

Introduction: Autoimmune thyroiditis seems to be associated with increased cardiometabolic risk. Statins, the mainstay of cardiovascular risk reductio......

Experimental Investigations of Monomethyl and Dimethyl Fumarate in an Astrocyte-Microglia Co-Culture Model of Inflammation

期刊: PHARMACOLOGY, 2023; 108 (2)

Introduction: Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating disease of the central nervous system. Dimethyl fumarate ......

Matrine Protects Endothelial Progenitor Cells against Apoptosis and Promotes Their Migration, Invasion, and Tube Formation Abilities via Modulating miR-126b/FOXO4 Axis

期刊: PHARMACOLOGY, 2023; 108 (4)

Introduction and Objective: Endothelial progenitor cells (EPCs) have been proven to exhibit a therapeutic effect in deep vein thrombosis, but are susc......

Population Pharmacokinetic Modeling to Inform Sertraline Dosing Optimization in Patients with Depression

期刊: PHARMACOLOGY, 2023; 108 (4)

Sertraline is one of the most prescribed antidepressants, but its pharmacokinetic (PK) properties are still not completely characterized. Using nonlin......

The Effects of Novel Triazolopyrimidine Derivatives on H2S Production in Lung and Vascular Tonus in Aorta

期刊: PHARMACOLOGY, 2023; 108 (6)

Introduction: Hydrogen sulfide (H2S), known as a third gasotransmitter, is a signaling molecule that plays a regulatory role in physiological and path......

Targeting Breast Cancer Signaling via Phytomedicine and Nanomedicine

期刊: PHARMACOLOGY, 2023; 108 (6)

Background: The development of breast cancer (BC) and how it responds to treatment have both been linked to the involvement of inflammation. Chronic i......

DPP4 Inhibitor Sitagliptin Reduces Inflammatory Responses and Mast Cell Activation in Allergic Rhinitis

期刊: PHARMACOLOGY, 2023; 108 (2)

Introduction: DPP4 is thought to be involved in certain immune processes and plays an important role in allergic reactions in the lungs. The effect of......

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