期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 247 ()
Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality due to chronic arterial injury caused by hyperlipidemia, hypertensi......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 249 ()
Lowering blood cholesterol levels efficiently reduces the risk of developing atherosclerotic cardiovascular disease (ASCVD), including coronary artery......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 249 ()
Benzodiazepine, a classical medication utilized in the treatment of insomnia, operates by augmenting the activity of the GABAA receptor. This undersco......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 241 ()
Morphine prescribed for analgesia has caused drug-related deaths at an estimated incidence of 0.3% to 4%. Morphine has pharmacological properties that......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 242 ()
Extracellular vesicles (EVs) are cell-derived membrane vesicles composed of a lipid bilayer. EVs contain biological molecules, such as nucleic acids, ......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 252 ()
During carcinogenesis, neoplastic cells accumulate mutations in genes important for cellular homeostasis, producing defective proteins. Viral infectio......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 247 ()
The resolution of inflammation is an essential endogenous process that protects host tissues from an exaggerated chronic inflammatory response. Multip......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 249 ()
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are three endogenously produced gases with important functions in the vasculature,......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 251 ()
The tumor microenvironment is surrounded by blood vessels and consists of malignant, non-malignant, and im-mune cells, as well as signalling molecules......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 244 ()
As one of the most prevalent and disabling brain disorders, epilepsy is characterized by spontaneous seizures that result from aberrant, excessive hyp......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 245 ()
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular functions such as cell proliferation, migration, surviv......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 250 ()
Obesity prevalence in the US has nearly tripled since 1975 anda parallel increase in prevalence of type 2 diabetes (T2D). Obesity promotes a myriad of......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 241 ()
Despite significant advances in the screening, diagnosis, and treatment of colorectal cancer (CRC) immune checkpoint inhibitors (ICIs) continue to hav......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 248 ()
Vitamin A (VA, retinol) and its metabolites (commonly called retinoids) are required for the proper development of the kidney during embryogenesis, bu......
期刊： PHARMACOLOGY & THERAPEUTICS, 2023; 241 ()
Extensive injury of endothelial cells in blood vasculature, especially in the microcirculatory system, frequently oc-curs in hosts suffering from seps......
