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Retinoic acid signaling pathway perturbation impacts mesodermal-tissue development in the zebrafish embryo: Biomarker candidate identification using transcriptomics.

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 119 ()

The zebrafish embryo (ZE) model provides a developmental model well conserved throughout vertebrate embryogenesis, with relevance for early human embr......

Aflatoxin B1-induced dysfunction in male rats' reproductive indices were abated by Sorghum bicolor (L.Moench) hydrophobic fraction

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 120 ()

The burden of infertility distresses millions of families worldwide. The harmful effects of aflatoxin B1 (AFB1) on the reproductive system involve oxi......

Early-life exposure to acephate inhibits sexual development and induces testicular and ovarian toxicity in mice

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 121 ()

Acephate is an organophosphate insecticide that exerts its toxicity by acting on the nervous system of insects. In addition to its action on the mamma......

Folate in maternal rheumatoid arthritis-filial autism spectrum disorder continuum

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 115 ()

Rheumatoid Arthritis (RA) is an inflammatory autoimmune disease that affects women three times more than men. Epidemiological studies found that the i......

Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 118 ()

Paclitaxel (PTX) is widely used to treat a number of malignancies, although it has toxic side effects. Hesperidin (HES) has a wide range of biological......

Pre- and postnatal developmental exposure to the polychlorinated biphenyl mixture aroclor 1221 alters female rat pituitary gonadotropins and estrogen receptor alpha levels

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 118 ()

Polychlorinated-biphenyls (PCBs) are industrial compounds, which were widely used in manufacturing of electrical parts and transformers. Despite being......

Maternal folate and metabolic programming of the offspring: A systematic review of the literature

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 120 ()

There is emerging evidence suggesting that folate status during pregnancy may play a role in fetal programming of metabolic disease. Therefore, this s......

Maternal exposure to di(2-ethylhexyl) phthalate (DEHP) causes multigenerational adverse effects on the uterus of F1 and F2 offspring rats

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 115 ()

Phthalates are one of the ubiquitous chemicals found in day-to-day products like food packaging, children's toys, and other consumer commodities. Ther......

Oxidative stress in the ovaries of mice chronically exposed to a low lead concentration: A generational approach

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 115 ()

Lead (Pb) is a heavy metal that alters the oxidation-reduction balance, affecting reproductive health and transfer during pregnancy and lactation. How......

Developmental and reproduction toxicity studies of Biolimus A9 in SD rats

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 116 ()

Biolimus A9 (BA9) is a novel rapamycin derivative. In this report we evaluated the potential toxicity of BA9 in a developmental and reproduction toxic......

Nutrition, female fertility and in vitro fertilization outcomes

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 118 ()

The investigation of modifiable factors that may exert influences on female reproductive health and in vitro fertilization (IVF) outcomes is increasin......

Accentuated Hippo pathway and elevated miR-132 and miR-195a lead to changes of uteri and ovaries in offspring mice following prenatal exposure to vinclozolin

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 116 ()

Vinclozolin (VCZ) has been identified as a broad-spectrum fungicide and an environmental endocrine disruptor. Also, the Hippo signaling pathway contro......

Glyphosate exposure and preterm birth: A nested case-control pilot study

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 117 ()

Preterm birth (PTB) is associated with a high risk of infant mortality and long-term adverse health effects. Glyphosate is a broad-spectrum herbicide ......

Quantitative analysis of ovarian surface photographs as a tool for assessment of chemical effects on folliculogenesis and ovulation in rats

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 119 ()

Female reproductive toxicity assessments rely on histological evaluation of ovaries by hematoxylin & eosin (H & E)-stained cross-sections. Thi......

Spirulina (Arthrospira maxima) mitigates the toxicity induced by a mixture of metal and NSAID in Xenopus laevis

期刊: REPRODUCTIVE TOXICOLOGY, 2023; 120 ()

Cadmium (Cd) is often detected in the environment due to its wide use in industry; also, NSAIDs are one of the most consumed pharmaceuticals, particul......

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