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Principles and functions of pericentromeric satellite DNA clustering into chromocenters

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 128 ()

Simple non-coding tandem repeats known as satellite DNA are observed widely across eukaryotes. These repeats occupy vast regions at the centromere and......

JIF:6.273

Neuronal identity and cognitive control dynamics in the PFC

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 129 ()

Adaptive behavior is supported by context-dependent cognitive control that enables stable and flexible senso-rimotor transformations. Impairments in t......

JIF:6.273

Nonclassical androgen and estrogen signaling is essential for normal spermatogenesis

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 121 ()

Signaling by androgens through androgen receptor (AR) is essential to complete spermatogenesis in the testis. Similarly, loss of the main estrogen rec......

JIF:6.273

The molecular clockwork of mammalian cells

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 126 ()

Most organisms contain self-sustained circadian clocks. These clocks can be synchronized by environmental stimuli, but can also oscillate indefinitely......

JIF:6.273

Kidney development to kidney organoids and back again

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 127 ()

Kidney organoid technology has led to a renaissance in kidney developmental biology. The complex underpinnings of mammalian kidney development have pr......

JIF:6.273

Mechanical control of tissue shape: Cell-extrinsic and -intrinsic mechanisms join forces to regulate morphogenesis

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 130 ()

During vertebrate development, cells must proliferate, move, and differentiate to form complex shapes. Eluci-dating the mechanisms underlying the mole......

JIF:6.273

Specification of the haematopoietic stem cell lineage: From blood-fated mesodermal angioblasts to haemogenic endothelium

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 127 ()

Haematopoietic stem and progenitor cells emerge from specialized haemogenic endothelial cells in select vascular beds during embryonic development. Sp......

JIF:6.273

Evolution of eukaryotic centromeres by drive and suppression of selfish genetic elements

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 128 ()

Despite the universal requirement for faithful chromosome segregation, eukaryotic centromeres are rapidly evolving. It is hypothesized that rapid cent......

JIF:6.273

Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 131 ()

The Metazoan complexity arises from a primary building block, the epithelium, which comprises a layer of polarized cells that divide the organism into......

JIF:6.273

Effect of varicoceles on spermatogenesis

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 121 ()

Varicoceles are dilated veins within the spermatic cord and a relatively common occurrence in men. Fortunately, the large majority of men are asymptom......

JIF:6.273

Fundamentals of bone vasculature: Specialization, interactions and functions

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 123 ()

Angiogenesis, hematopoiesis and osteogenesis are fundamental processes mediating complex and essential biological functions. In the bone marrow, endot......

JIF:6.273

Mechanistic origins of diverse genome rearrangements in cancer

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 123 ()

Cancer genomes frequently harbor structural chromosomal rearrangements that disrupt the linear DNA sequence order and copy number. To date, diverse cl......

JIF:6.273

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