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In the last 30 years, the field of aplastic anemia (AA), and more generally bone marrow failure syndromes, has undergone a multitude of new discoverie......

Tribute to an editor: Neal S. Young As a Medical Editor and Writer

Clinical picture of VITT

期刊： SEMINARS IN HEMATOLOGY, 2022; 59 (2)

This chapter explores the clinical features of vaccine-induced immune thrombotic thrombocytopenia, also called vaccine-induced immune thrombocytope-ni......

Collaborations, colleagues, and friendships: The Hematology Branch and blood disease centers in Asia

Hemolytic paroxysmal nocturnal hemoglobinuria: 20 years of medical progress

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by intravascular hemolysis, thrombosis and bone marrow failure. Prior to the availability o......

Somatic mutations in VEXAS Syndrome and Erdheim-Chester disease: Inflammatory myeloid diseases

Somatic mutations have been increasingly identified as etiologic for many hematologic and autoinflammatory disorders. VEXAS (vacuoles, E1 enzyme, X-li......

Clinical manifestations of clonal hematopoiesis: What has SF3B1-mutant MDS taught us?

Large scale high-throughput DNA sequencing studies have identified clonal hematopoiesis (CH) as a clin-ical phenomenon characterized by a disproportio......

Somatic compensation of inherited bone marrow failure

Inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of genetic disorders characterized by insufficient blood cell production and......

Immunosuppressive therapy in severe aplastic anemia

Severe aplastic anemia, a disease characterized by pancytopenia and a hypocellular marrow, is treatable by either immunosuppressive therapy (IST) or h......

Clonality in immune aplastic anemia: Mechanisms of immune escape or malignant transformation

Aplastic anemia (AA) is the prototypic bone marrow failure syndrome and can be classified as either ac-quired or inherited. Inherited forms are due to......

Somatic mutations and clonal expansions in paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder caused by a mutation of the X-linked PIGA gene, resul......

The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty?s syndrome

T cell large granular lymphocyte leukemia (T-LGLL) is an interesting case at the intersection of autoim-munity and cancer. In T-LGLL, T cells with som......

Aplastic anemia: Pathophysiology

Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions characterized by uni-or multi-lineage marrow and/or p......

Somatic mutations in acquired pure red cell aplasia ?

Acquired pure red cell aplasia (PRCA) is a syndrome characterized by anemia and a marked reduction of erythroid progenitor cells with various etiologi......

Laboratory testing for VITT antibodies

期刊： SEMINARS IN HEMATOLOGY, 2022; 59 (2)

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a highly prothrombotic disorder that like heparin-induced thrombocytopenia (HIT) is cause......