Lipid droplets (LDs) are involved in viral infections, but exactly how remains unclear. Here, we study the hepatitis C virus (HCV) whose core capsid p......
Withdrawn: Prostaglandin E2 promotes retinal microvascular endothelial cell-derived miR-423-5p-containing extracellular vesicles inducing Muller cell ......
Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins......
TLR4 is activated by the bacterial endotoxin lipopolysaccharide (LPS) and triggers two proinflammatory signaling cascades: a MyD88-dependent one in th......
The intracellular trafficking of beta-site amyloid precursor protein (APP) cleaving enzyme (BACE1) and APP regulates amyloid-beta production. Our prev......
Alpha-synuclein (alpha-Syn), an intrinsically disordered protein (IDP), is associated with neurodegenerative disorders, including Parkinson's disease ......
Fission yeast cytokinesis is driven by simultaneous septum synthesis, membrane furrowing and actomyosin ring constriction. The septum consists of a pr......
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson's disease. A plethora of evidence has i......
The extremely dynamic life cycle of gap junction connections requires highly efficient intracellular trafficking system especially designed for gap ju......
Most enveloped viruses infect cells by binding receptors at the cell surface and undergo trafficking through the endocytic pathway to a compartment wi......
Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles. Lysosomes were regarded as exc......
The endoplasmic reticulum (ER)-to-Golgi intermediate compartment (ERGIC) is a membranous organelle that mediates protein transport between the ER and ......
Mitochondria and intermediate filament (IF) accumulations often occur during imbalanced axonal transport leading to various types of neurological dise......
Both constitutive and regulated secretion require cell organelles that are able to store and release the secretory cargo. During development, the larv......
The budding of intralumenal vesicles (ILVs) at endosomes requires membrane scission by the ESCRT-III complex. This step is negatively regulated in yea......
