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Many or too many progesterone membrane receptors? Clinical implications

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (12)

Several receptors for nongenomically initiated actions of progesterone (P4) exist, namely membrane-associated P4 receptors (MAPRs), membrane progestin......

JIF:7.713

Assessment and treatment of osteoporosis and fractures in type 2 diabetes

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (5)

There is substantial, and growing, evidence that type 2 diabetes (T2D) is associated with skeletal fragility, despite often preserved bone mineral den......

JIF:7.713

Growth variations with opposite clinical outcomes and the emerging role of IGF-1

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (5)

Normal growth pattern variations [i.e., constitutional advancement and constitu-tional delay of growth and puberty (CAGP and CDGP)] are the mirror ima......

JIF:7.713

What puts the heat on thermogenic fat: metabolism of fuel substrates

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (8)

Owing to its unique capacity to clear macronutrients from circulation and use them to produce heat, thermogenic fat is capable of regulating glucose, ......

JIF:7.713

Cortisol and cardiometabolic disease: a target for advancing health equity

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (11)

Stress, in both intrinsic psychosocial and extrinsic physical environmental forms, can impact the development of, and outcomes in, cardiovascular dise......

JIF:7.713

Adipocyte extracellular vesicles: rescuers of cardiac mitochondrial stress

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (1)

Nutrient excess induces mitochondrial dysfunction, which participates in obesity-related complications. Obesity also associates with high cardiac oxid......

JIF:7.713

OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (10)

The mitochondria are double-membrane organelles integral for energy metabolism. Mitochondrial dynamics is regulated by inner and outer mitochondrial m......

JIF:7.713

Energy as the cornerstone of environmentally driven sex allocation

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (10)

In recent years, observations of distinct organisms have linked the quality of the environment experienced by a given individual and the sex it will d......

JIF:7.713

Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horses

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (8)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets lipid-producing cells for viral tropism. In this review, we connect sys......

JIF:7.713

SIRT6: therapeutic target for nonalcoholic fatty liver disease

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (12)

Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cyto-plasmic SIRT6, which deacetylates and act......

JIF:7.713

Is high-intensity interval training harmful to health?

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (2)

High-intensity interval training (HIIT) is a common method to increase performance and promote health in elite sports, rehabilitation, and disease pre......

JIF:7.713

Microglial metabolic flexibility: emerging roles for lactate

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (3)

Microglia, the resident macrophages of the central nervous system (CNS), play important functions in the healthy and diseased brain. In the emerging f......

JIF:7.713

Shifting metabolism to increase lifespan

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (8)

Lionaki et al. report that reducing mitochondrial protein import in-creases Caenorhabditis elegans lifespan, through a metabolic shift that enhances t......

JIF:7.713

NAFLD and thyroid function: pathophysiological and therapeutic considerations

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (11)

Nonalcoholic fatty liver disease (NAFLD) is a worldwide rising challenge because of hepatic, but also extrahepatic, complications. Thyroid hormones ar......

JIF:7.713

The time is now for new, lower diabetes diagnostic thresholds

期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2022; 33 (1)

Current thresholds for diagnosing diabetes are outdated and do not represent advancements in disease understanding or ability to impact course. Today,......

JIF:7.713

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