期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (11)
Targeted protein degradation (TPD) technologies, particularly proteolysis-targeting chimeras (PROTACs), have emerged as a significant advancement in d......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (8)
G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent wor......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (10)
Elevated phosphoinositide 3-kinase (PI3K) activity in human tumors has prompted widespread efforts to develop chemical PI3K inhibitors for oncology in......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (2)
Synonymous gene recoding, the substitution of synonymous variants into the genetic sequence, has been used to overcome many production limitations in ......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (10)
Rational drug design for G protein-coupled receptors (GPCRs) remains a challenging area. A new study from the Xu, Roth, and Zhang groups provides a co......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (8)
Ferroptosis is a distinct form of cell death driven by the accumulation of peroxidized lipids. Characterized by alterations in redox lipid metabolism,......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (11)
The adaptation of natural killer (NK) cells to conditions in the microenvironment of tumors is deeply affected by their metabolic activity, itself a r......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (12)
The Notch pathway regulates a diverse array of cell fate decisions, making it an enticing target in cancer therapy and regenerative medicine. During t......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (10)
Since May 2022, mpox virus (MPXV) has attracted considerable attention due to a multi-country outbreak. Marked differences in epidemiology, transmissi......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (11)
DNA-encoded chemical library technology (DECL or DEL) has become an impor-tant pillar for small-molecule drug discovery. The technology rapidly identi......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (1)
A multicountry outbreak of monkeypox has gained global attention. Basic research including structural and immunological in(MPXV) is central to design ......
期刊： TRENDS IN PHARMACOLOGICAL SCIENCES, 2023; 44 (2)
Monoclonal antibodies represent an exciting class of therapeutics against respiratory viral infections. Notwithstanding their specificity and affinity......
