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Basic fibroblast growth factor inhibits aortic valvular interstitial cells calcification via Notch1 pathway

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (4)

Calcific aortic valve disease (CAVD) is an active pathological process mediated by abnormal activation and transdifferentiation of valvular interstiti......

JIF:2.291

A model established using marital status and other factors from the Surveillance, Epidemiology, and End Results database for early stage gastric cancer

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (6)

Currently, the postoperative prognosis of early stage gastric cancer (GC) is difficult to accurately predict. In particular, social factors are not fr......

JIF:2.291

Influence of cigarette smoking on oral microbiota in patients with recurrent aphthous stomatitis

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (3)

Recurrent aphthous stomatitis (RAS) is a common recurrent ulcerative disease of the oral mucosa which is closely related to oral microbial composition......

JIF:2.291

Efficacy and safety of endovascular therapy versus surgical clipping for patients with unruptured middle cerebral artery bifurcation aneurysms

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (5)

This study aims to evaluate the efficacy and safety of endovascular therapy versus neurosurgical clipping carried out for patients with unruptured mid......

JIF:2.291

Bronchodilatory effect of higenamine as antiallergic asthma treatment

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (8)

Asthma is a complex airway disease that affects more than 350 million humans worldwide. Allergic asthma symptoms are induced by Th2 immune response wi......

JIF:2.291

Investigating the demands for mobile internet-based home nursing services for the elderly

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (3)

The great value of home nursing services in the treatment of ailments in elderly patients has attracted increasing attention. This study describes a n......

JIF:2.291

Exploring the appropriate dose of nebulized hypertonic saline for bronchiolitis: a dose-response meta-analysis

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (1)

Nebulized hypertonic saline (HS) has gathered increasing attention in bronchiolitis. This study aims to evaluate the relationship between the dose of ......

JIF:2.291

Comparing the effects of twice-daily exenatide and insulin on renal function in patients with type 2 diabetes mellitus: secondary analysis of a randomized controlled trial

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (7)

This is a secondary analysis of a randomized controlled trial (RCT) on the effects of the glucagon-like peptide-1 receptor agonists exenatide and insu......

JIF:2.291

Sequential administration of pemetrexed and cisplatin reprograms tumor immune microenvironment and potentiates PD-1/PD-L1 treatment in a lung cancer model

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (3)

This article aimed to investigate the effects of the administration method of pemetrexed and cisplatin on the efficacy and safety of treating non-smal......

JIF:2.291

Vinpocetine enhances cisplatin sensitivity of non-small cell lung cancer cells by reducing the nuclear factor erythroid 2-related factor 2 signaling

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (6)

Vinpocetine exerts pharmacological effects against cardiovascular diseases, while few studies focused on its roles in cancer. The present study invest......

JIF:2.291

Predictive role of ultrasound remission for progressive ultrasonography-detected structural damage in patients with rheumatoid arthritis

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (2)

Regarding the persistence of subclinical synovitis, the concept of ultrasound remission has been proposed in addition to clinical remission. However, ......

JIF:2.291

Process analysis of anthracycline adverse reactions in breast cancer patients with postoperative chemotherapy

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (6)

This study aimed to explore the clinical adverse effects of anthracyclines on patients undergoing chemotherapy after breast cancer surgery. A total of......

JIF:2.291

Anti-apoptosis effects of codonolactone on cerebral ischemia-reperfusion injury

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (5)

Codonolactone is the main biologically active ingredient in Atractylodes lancea. Studies have shown various functions of codonolactone, while its prot......

JIF:2.291

Effects of maslinic acid on cardiac function in ischemia-reperfusion injury rats

期刊: JOURNAL OF INVESTIGATIVE MEDICINE, 2022; 70 (1)

Maslinic acid (MA), a pentacyclic triterpenoid, has been reported to exert broad pharmacological properties. However, it is still unclear whether MA e......

JIF:2.291

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