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Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia

期刊: BEHAVIOURAL PHARMACOLOGY, 2021; 32 (7)

Patients diagnosed with schizophrenia have been reported to exhibit atypically low pain sensitivity and to vary in their experience of chronic pain. T......

Antidepressant-like effects of dezocine in mice: involvement of 5-HT1A and kappa opioid receptors

期刊: BEHAVIOURAL PHARMACOLOGY, 2021; 32 (6)

Dezocine is an opioid with low efficacy at mu-opioid and kappa-opioid receptors. It also inhibits the reuptake of norepinephrine and serotonin. Dezoci......

Alteration of the PKA-CREB cascade in the mPFC accompanying prepulse inhibition deficits: evidence from adolescent social isolation and chronic SKF38393 injection during early adolescence

期刊: BEHAVIOURAL PHARMACOLOGY, 2021; 32 (6)

Prepulse inhibition (PPI) refers to the inhibition of the startle reflex that occurs when the startling stimulus is preceded by a weak prestimulus. Al......

Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice

期刊: BEHAVIOURAL PHARMACOLOGY, 2021; 32 (1)

We have reported that SMIP004, an inhibitor of S-phase kinase-associated protein 2 (Skp2), displays antidepressant-like activities in stress-naive and......

Effect of heat shock protein 70 modulators on the development of morphine analgesic tolerance in rats

期刊: BEHAVIOURAL PHARMACOLOGY, 2020; 31 (2-3)

The clinical use of opioid analgesics, such as morphine, is limited by analgesic tolerance, molecular mechanism of which is not well understood. Recen......

A further assessment of a role for Toll-like receptor 4 in the reinforcing and reinstating effects of opioids

期刊: BEHAVIOURAL PHARMACOLOGY, 2020; 31 (2-3)

The Toll-like receptor 4 (TLR4) antagonists, (+)-naloxone and (+)-naltrexone, have been reported to decrease self-administration of opioids in rats an......

Evaluation of the antidepressive property of beta-hydroxybutyrate in mice

期刊: BEHAVIOURAL PHARMACOLOGY, 2020; 31 (4)

beta-hydroxybutyrate, a ketone body metabolite, has been shown to suppress depression-like behavior in rodents. In this study, we examined its antidep......

Metoprolol decreases retention of fear memory and facilitates long-term depression in lateral amygdala

期刊: BEHAVIOURAL PHARMACOLOGY, 2020; 31 (6)

Posttraumatic stress disorder is a mental disorder with a known cause, yet effective behavioral and pharmacotherapies remain elusive for many afflicte......

Neuroprotective effects of Danshensu in Parkinson's disease mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

期刊: BEHAVIOURAL PHARMACOLOGY, 2019; 30 (1)

Parkinson's disease (PD) causes major changes in dopaminergic neurons of the brain, resulting in motor symptoms in older adults. A previous study show......

JIF:1.79

Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation

期刊: BEHAVIOURAL PHARMACOLOGY, 2019; 30 (4)

Isolation rearing produces significant behavioral and neurochemical dysfunctions in rodents, which resemble the symptoms of schizophrenia. Clozapine, ......

JIF:1.79

Further pharmacological comparison of d-methamphetamine and l-methamphetamine in rats: abuse-related behavioral and physiological indices

期刊: BEHAVIOURAL PHARMACOLOGY, 2019; 30 (5)

Previous preclinical research suggests that l-methamphetamine (l-MA) has potential therapeutic utility to treat psychostimulant abuse. This study exam......

JIF:1.79

Effects of N-ethylpentylone on locomotor activity and anxiety-like behavior in rats

期刊: BEHAVIOURAL PHARMACOLOGY, 2019; 30 (6)

N-ethylpentylone (NEP), a new synthetic cathinone, has been rising to be one of the most popular cathinone derivatives in recent years. However, resea......

JIF:1.79

Sevoflurane-induced inflammation development: involvement of cholinergic anti-inflammatory pathway

期刊: BEHAVIOURAL PHARMACOLOGY, 2019; 30 (8)

Chronic inflammation plays an important role in the mechanisms underpinning the development of anesthesia-induced cognitive dysfunction. However, less......

JIF:1.79

Piperlongumine produces antidepressant-like effects in rats exposed to chronic unpredictable stress

期刊: BEHAVIOURAL PHARMACOLOGY, 2019; 30 (8)

Piperlongumine, an alkaloid compound extracted from Peper longum L, has been reported to produce neuroprotective effects in the brain and exert variou......

JIF:1.79

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons in rats associated with the increased endophilin A2 expression

期刊: BEHAVIOURAL PHARMACOLOGY, 2019; 30 (8)

The brain renin-angiotensin system plays a vital role in the modulation of the neuroinflammatory responses and the progression of dopaminergic (DA) de......

JIF:1.79

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