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SYNTHESIS OF LESINURAD VIA A MULTICOMPONENT REACTION WITH ISOCYANIDES AND DISULFIDES

期刊: HETEROCYCLES, 2020; 100 (7)

An efficient synthesis of Lesinurad, a selective uric acid reabsorption (URAT1) inhibitor, is described in this article. The route to synthesis of Les......

RECYCLABLE TRIPHENYLBISMUTH(V) BISPERFLUORO-OCTANESULFONATE CATALYZED SYNTHESIS OF DIHYDROPYRIMIDINONES

期刊: HETEROCYCLES, 2020; 100 (7)

Triphenylbismuth(V) bisperfluorooctanesulfonate Ph3Bi(OSO2C8F17)(2) was successfully synthesized by treatment of Ph3BiCl2 with C8F17SO2OAg, and was fo......

RUMPHELLOLIDE K, A NOVEL C-3/8 ETHER LINKAGE CARYOPHYLLANE FROM RUMPHELLA ANTIPATHES

期刊: HETEROCYCLES, 2020; 100 (9)

Chemical examination of Rumphella antipathes, collected in the waters of Taiwan, led to the isolation of a novel caryophyllane sesquiterpenoid, rumphe......

IMPROVED SYNTHESIS OF CYCLOHEXANE-BACKBONE IRIDIUM-COMPLEXES OF QUINOLINE-PHOSPHINE AND THEIR APPLICATIONS IN ASYMMETRIC HYDROGENATION

期刊: HETEROCYCLES, 2020; 100 (9)

The iridium-complexes 3 and 4 with cyclohexane-backbone derived from quinoline were easily synthesized. The key step is cis/trans stereoselective redu......

SYNTHESIS AND FLUORESCENCE OF 9-BENZYL-9H-CARBAZOLE DERIVATIVES AND ITS APPLICATION FOR RECOGNITION OF RARE EARTH CATIONS

期刊: HETEROCYCLES, 2020; 100 (4)

The synthesis and photophysical properties of 9-benzyl-9H-carbazole derivatives have been investigated. A novel ethyl 9-benzyl-1-methyl-9H-carbazole-2......

LACTAMIZATION OF ALKENYL C-H BONDS TO GENERATE 2-QUINOLINONES WITH TRIPHOSGENE

期刊: HETEROCYCLES, 2020; 100 (4)

A simple and easy-going method is developed to synthesize the analogues of 2-quinolinones by using triphosgene (BTC) as the carbonyl source. In these ......

Ag(I)/SEC-AMINE-AMIDPHOS-CATALYZED ENDO-STEREOSELECTIVE SYNTHESIS OF FULLY SUBSTITUTED PYRROLIDINES VIA 1,3-DIPOLAR CYCLOADDITION BASED ON AZOMETHINE YLIDES

期刊: HETEROCYCLES, 2020; 100 (4)

Cooperative catalysis using multifunctional organic scaffolds in combination with transition-metal ions is emerging as a powerful tool in asymmetric s......

IDENTIFICATION AND QUANTIFICATION OF ALKALOID COMPOUNDS FROM DIFFERENT PARTS AND PRODUCTION AREAS OF DATURA METEL L.

期刊: HETEROCYCLES, 2020; 100 (4)

An ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) method was used to identif......

ABSOLUTE CONFIGURATION OF THE BUTENOLIDE OF ABIETANE

期刊: HETEROCYCLES, 2020; 100 (4)

17-Hydroxyjolkinolide A-B (1-2) and jolkinolide A-B (3-4) are four ent-13(15)-abietane-16,12-olide type diterpenoids isolated from the roots of Euphor......

BIS(1,3-DIMETHYLIMIDAZOLIDINONE) HYDROTRIBROMIDE (DITB) PROMOTED MULTICOMPONENT REACTION FOR THE SYNTHESIS OF HIGHLY FUNCTIONALIZED PIPERIDINES

期刊: HETEROCYCLES, 2020; 100 (4)

A convenient and efficient method has been developed for the synthesis of highly functionalized piperidines via three-component, one-pot domino reacti......

SYNTHESIS AND CYTOTOXIC EVALUATION OF STEROIDAL ENDOPEROXIDE DERIVATIVES WITH HYDRAZIDE SIDE CHAIN AS ANTICANCER AGENTS

期刊: HETEROCYCLES, 2020; 100 (5)

A series of novel steroidal 5 alpha,8 alpha-endoperoxide derivatives bearing hydrazide side chain were synthesized and evaluated for their cytotoxicit......

DESIGN, SYNTHESIS AND IN VITRO ANTIFUNGAL EVALUATION OF NOVEL TRIAZOLE DERIVATIVES

期刊: HETEROCYCLES, 2020; 100 (5)

As a part of our continuing research on triazole derivatives antifungal agents, 10 novel target compounds containing 1,2,4-triazole moiety were synthe......

REGIOSELECTIVE SYNTHESIS OF QUINOXALIN-2-ONE DERIVATIVES REGULATED BY ACID AND BASE

期刊: HETEROCYCLES, 2020; 100 (5)

A concise approach for the synthesis of quinoxalin-2-one derivatives through substituted o-phenylenediamines and alpha-ketoester with high regioselect......

FACILE SYNTHESIS OF 2-ARYL(GUAIAZULEN-1-YL)METHYLKOJIC ACID DERIVATIVES VIA BENZYLATION

期刊: HETEROCYCLES, 2020; 100 (6)

A facile and efficient one-pot procedure for the preparation of 2-aryl(guaiazulen-l-yl)methylkojic acid derivatives by a catalyst-free, benzylation of......

RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE

期刊: HETEROCYCLES, 2020; 100 (6)

A facile synthesis of hydroxymethylated N-aryl-azaindoles was developed via a Ru(II)-catalyzed regioselective C-H addition to paraformaldehyde. The re......

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