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Inhibition of PRMT6 reduces neomycin-induced inner ear hair cell injury through the restraint of FoxG1 arginine methylation

期刊: INFLAMMATION RESEARCH, 2022; 71 (3)

Objective Hair cells in the inner ear have been demonstrated to be sensitive to the ototoxicity from some beneficial pharmaceutical drugs. This study ......

JIF:4.114

Splenic T lymphocytes induce the formation of immunosuppressive neutrophils through IFN-gamma in sepsis

期刊: INFLAMMATION RESEARCH, 2022; 71 (1)

Background Despite many advances in treatment, the prognosis of patients with sepsis still remains poor. Polymorphonuclear leukocytes (PMNs) are the f......

JIF:4.114

Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury

期刊: INFLAMMATION RESEARCH, 2022; 71 (2)

Objective Trimetazidine (TMZ) exerts a strong inhibitory effect on ischemia/reperfusion (I/R) injury. Inflammation plays a key role in I/R injury. We ......

JIF:4.114

Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice

期刊: INFLAMMATION RESEARCH, 2022; 71 (10-11)

Background and objective Acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS) was increasingly recognized as one of the most severe acu......

JIF:4.114

C/EBP beta enhances immunosuppression activity of myeloid-derived suppressor cells by a P300-mediated acetylation modification

期刊: INFLAMMATION RESEARCH, 2022; 71 (12)

Objective Myeloid-derived suppressor cells (MDSCs) are a major immunosuppressive population in the tumor microenvironment,inhibiting anti-tumor immune......

JIF:4.114

MiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6

期刊: INFLAMMATION RESEARCH, 2022; 71 (2)

Objective This study aimed to investigate the relationship between miR-21 and lipopolysaccharide (LPS)-induced myocardial injury and its molecular and......

JIF:4.114

Bioinformatics analysis for identifying micro-RNAs, long noncoding RNAs, transcription factors, and immune genes regulatory networks in diabetic cardiomyopathy using an integrated bioinformatics analysis

期刊: INFLAMMATION RESEARCH, 2022; 71 (7-8)

Objectives We identified functional genes and studied the underlying molecular mechanisms of diabetic cardiomyopathy (DCM) using bioinformatics tools.......

JIF:4.114

Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice

期刊: INFLAMMATION RESEARCH, 2022; 71 (4)

Objective The transient receptor potential vanilloid subtype 1 (TRPV1) channel is considered to play an important regulatory role in the process of pa......

JIF:4.114

Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-kappa B signaling pathway

期刊: INFLAMMATION RESEARCH, 2022; 71 (9)

Background Acute pancreatitis (AP) is an inflammatory process of the pancreas resulting from biliary obstruction or alcohol consumption. Approximately......

JIF:4.114

Immune response associated with ischemia and reperfusion injury during organ transplantation

期刊: INFLAMMATION RESEARCH, 2022; 71 (12)

Background Ischemia and reperfusion injury (IRI) is an ineluctable immune-related pathophysiological process during organ transplantation, which not o......

JIF:4.114

H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion

期刊: INFLAMMATION RESEARCH, 2022; 71 (1)

Objective The CagA (cytotoxin-related gene A, CagA) protein is an important factor for the pathogenicity of Helicobacter pylori (H. pylori). Although ......

JIF:4.114

A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes: geniposide suppresses HIF-1 alpha accumulation in the hypoxic microenvironment of synovium

期刊: INFLAMMATION RESEARCH, 2022; 71 (10-11)

Objective The excessive proliferation of fibroblast-like synoviocytes (FLSs) is a key inducement for the occurrence and development of rheumatoid arth......

JIF:4.114

Inhibition of visfatin alleviates sepsis-induced intestinal damage by inhibiting Hippo signaling pathway

期刊: INFLAMMATION RESEARCH, 2022; 71 (7-8)

Background The aim of this study is to investigate role of Visfatin, one of the pro-inflammatory adipokines, in sepsis-induced intestinal injury and t......

JIF:4.114

IL-38, a potential therapeutic agent for lupus, inhibits lupus progression

期刊: INFLAMMATION RESEARCH, 2022; 71 (7-8)

Background Previous studies reported that IL-38 was abnormally expressed in patients with systemic lupus erythematosus (SLE). However, the involvement......

JIF:4.114

Lipoxin alleviates oxidative stress: a state-of-the-art review

期刊: INFLAMMATION RESEARCH, 2022; 71 (10-11)

Objective This review aims to summarize the capability of lipoxin in regulating oxidative stress. Background Oxidative stress is defined as an imbalan......

JIF:4.114

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