期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (1)
Introduction: Androgen Receptor (AR) plays a pivotal role in the development of male sex and contributes to prostate cancer growth. Different from oth......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (1)
Introduction: Carboxyalkyl flavonoids derivatives are considered as effective inhibitors in reducing post-prandial hyperglycaemia. Methods: Combined w......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (1)
Background: Glycogen synthase kinase-3 (GSK3) is associated with various key biological processes and has been considered as an important therapeutic ......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (3)
Background: Insulin-dependent Diabetes Mellitus Type 1 (T1D) also referred to as autoimmune diabetes. T1D is a chronic disease which is characterized ......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (3)
Background: Prostate cancer is one of the most common tumors in the world and the fifth leading cause of male cancer death. Although the treatment of ......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (3)
Background: B-Raf(V)(600E) kinase was identified as an important target in current cancer treatment, and the type II B inhibitors show good qualities ......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (4)
Background: Vitamin E is comprised of alpha, beta, gamma and delta-tocopherols (Ts) and alpha, beta, gamma and delta- tocotrienols (T3s). Vitamin E ha......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (4)
Background: Bioisosteric replacement is widely used in drug design for lead optimization. However, the identification of a suitable bioisosteric group......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (5)
Background: HIV-1 Integrase (IN) is an important target for the development of the new anti-AIDS drugs. HIV-1 LEDGF/p75 inhibitors, which block the in......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (5)
Background: Pyrazol-5-amine derivatives are an important class of heterocyclic compounds. However, there are less 4-alkyl substituted pyrazoles report......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2020; 16 (6)
Introduction: The research and development of drugs, related to the central nervous system (CNS) diseases is a long and arduous process with high cost......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2019; 15 (2)
Introduction: The development of a novel drug is an extremely complicated process that includes the target identification, design and manufacture, and......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2019; 15 (3)
Introduction: Machine Learning is a useful tool for the prediction of cell-penetration compounds as drug candidates. Materials and Methods: In this st......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2019; 15 (3)
Introduction: Acetyl-CoA Carboxylases (ACC) have been an important target for the therapy of metabolic syndrome, such as obesity, hepatic steatosis, i......
期刊： CURRENT COMPUTER-AIDED DRUG DESIGN, 2018; 14 (1)
Background: Infectious disease is increasingly hampering human health, which challenge the discovery of new antibacterial target. Peptide deformylase ......
