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Apatinib as second-line or later therapy in patients with advanced hepatocellular carcinoma (AHELP): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial

期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021; 6 (7)

Background Inhibition of vascular endothelial growth factor receptor (VEGFR) has shown antitumour activity in advanced hepatocellular carcinoma, but f......

Gastrointestinal sequelae 90 days after discharge for COVID-19

期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021; 6 (5)

lead to altered infectivity, virulence, and severity. What effect this will have on patients with IBD remains to be seen. A notable additional conside......

The role of precision nutrition in the modulation of microbial composition and function in people with inflammatory bowel disease

期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021; 6 (9)

Inflammatory bowel diseases, principally Crohn's disease and ulcerative colitis, are multifactorial chronic conditions. Alterations in gut microbial p......

Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis

期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021; 6 (3)

Background Diagnostic tools for liver disease can now include estimation of the grade of hepatic steatosis (S0 to S3). Controlled attenuation paramete......

Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis

期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021; 6 (7)

Background Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet its largest trial detected minimal benefit for a ......

Effect of a deep learning-based system on the miss rate of gastric neoplasms during upper gastrointestinal endoscopy: a single-centre, tandem, randomised controlled trial

期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021; 6 (9)

Background White light endoscopy is a pivotal first-line tool for the detection of gastric neoplasms. However, gastric neoplasms can be missed during ......

The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis

期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021; 6 (6)

Findings Of the 6863 publications identified, 70 articles describing 73 randomised controlled trials were included in our analysis. The pooled placebo......

Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial

期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021; 6 (2)

Background Peritoneal recurrence of gastric cancer after curative surgical resection is common and portends a poor prognosis. Early studies suggest th......

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