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Bone morphogenetic protein 2 controls steroid-induced osteonecrosis of the femoral head via directly inhibiting interleukin-34 expression

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (1)

Increased inflammatory response is one of the major characteristics of osteonecrosis of the femoral head (ONFH). We aimed to investigate the function ......

JIF:4.613

GPER mediates the IL6/JAK2/STAT3 pathway involved in VEGF expression in swine ovary GCs

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (1)

Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis in ovaries, particularly during follicular development and ovulation. I......

JIF:4.613

Synoviolin inhibits the inflammatory cytokine secretion of Muller cells by reducing NLRP3

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (2)

The pro-inflammatory cytokines secreted by Muller cells aggregate retinal cell loss and vascularization in diabetic retinopathy (DR). The deubiquitina......

JIF:4.613

Quercetin protects rat BMSCs from oxidative stress via ferroptosis

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (3)

Quercetin has been shown to have a wide range of beneficial effects, such as anti-inflammation, anti-oxidation and immunomodulation. The study was des......

JIF:4.613

miR-146a promotes M2 macrophage polarization and accelerates diabetic wound healing by inhibiting the TLR4/NF-kappa B axis

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (2)

We tried to unveil the clinical significance of miR-146a as a biomarker in M2 macrophage polarization in diabetic wound healing. Initially, we found r......

JIF:4.613

miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (1)

miR-23a-3p and miR-23b-3p are members of the miR-23 similar to 27 similar to 24 similar to 2 superfamily. The role of miR-23a/b-3p in regulating hepat......

JIF:4.613

Effects of melatonin on the production of GnRH and LH in luteal cells of pregnant sows

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (2)

Effects of melatonin on the release and synthesis of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) at the hypothalamus and pituit......

JIF:4.613

MCAD activation by empagliflozin promotes fatty acid oxidation and reduces lipid deposition in NASH

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (3)

Medium-chain acyl-CoA dehydrogenase (MCAD) is one of the significant enzymes involved in the beta-oxidation of mitochondrial fatty acids. MCAD deficie......

JIF:4.613

Pathological changes and oxidative stress of the HPG axis in hypothyroid rat

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2021; 67 (3)

Hypothyroidism is a common endocrine disease caused by a deficiency of thyroid hormones, which could affect the hypothalamus-pituitary-gonadal (HPG) a......

The dual role of RFX6 in directing beta cell development and insulin production

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2021; 66 (2)

RFX6 transcription factor is believed to play a central role in directing cell development of insulin-producing pancreatic islet. RFX6 homozygous muta......

Collagen type 1 enhances cell growth and insulin biosynthesis in rat pancreatic cells

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2021; 67 (3)

Type I collagen (collagen I) is the most abundant component of the extracellular matrix (ECM) in the pancreas. We previously reported that collagen I-......

ACOX1, regulated by C/EBP alpha and miR-25-3p, promotes bovine preadipocyte adipogenesis

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2021; 66 (3)

Acyl-coenzyme A oxidase 1 (ACOX1) is the first and rate-limiting enzyme in peroxisomal fatty acid beta-oxidation of fatty acids. Previous studies have......

NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2021; 67 (2)

Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal-induced nucleotide-binding oligomerization domain (NO......

Inhibiting PDGF-D alleviates the symptoms of HELLP by suppressing NF-kappa B activation

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2021; 66 (3)

Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a life-threatening pregnancy complication. Though there are several medi......

Sodium vitamin C transporter 2 orchestrates lactate metabolism in mouse Sertoli cells

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2021; 66 (2)

Transportation of vitamin C (also called ascorbic acid (AA)), an important watersoluble antioxidant and cofactor in testis, requires glucose transport......

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