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Molecular phenotypes reveal heterogeneous engraftments of patient-derived hepatocellular carcinoma xenografts

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (4)

Objective: Patient-derived xenograft (PDX) models provide a promising preclinical platform for hepatocellular carcinoma (HCC). However, the molecular ......

Reappraise role of lymph node status in patterns of recurrence following curative resection of gastric adenocarcinoma

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (3)

Objective: To examine the association between lymph node status and recurrence patterns in completely resected gastric adenocarcinoma. Methods: We ret......

Current status and future perspectives on neoadjuvant therapy in gastric cancer

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (2)

Gastric cancer, with high morbidity and mortality rates, is one of the most heterogeneous tumors. Radical gastrectomy and postoperative chemotherapy a......

Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer: A prospective, multicenter, observational, non-interventional phase IV trial

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (4)

Objective: Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer (mCRC) worldwide and was......

Validation and modification of the AJCC 8th TNM staging system for pancreatic ductal adenocarcinoma in a Chinese cohort: A nationwide pancreas data center analysis

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (4)

Objective: To validate the 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC) in ......

Features of colorectal cancer in China stratified by anatomic sites: A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (4)

Objective: The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer. Ho......

Screening for gastric cancer in China: Advances, challenges and visions

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (2)

Gastric cancer (GC) is one of the major cancers in China and all over the world. Most GCs are diagnosed at an advanced stage with unfavorable prognosi......

Current status of lymph node dissection in gastric cancer

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (2)

Gastrectomy with lymph node (LN) dissection has been regarded as the standard surgery for gastric cancer (GC), however, the rational extent of lymphad......

Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (2)

Objective: The goal of this study was to get preliminary insight on the intra-tumor heterogeneity in colitis-associated cancer (CAC) and to reveal a p......

Clinical challenges in neoadjuvant immunotherapy for non-small cell lung cancer

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (2)

Immune checkpoint inhibitors (ICIs), a type of immunotherapy, have become one of the most important therapeutic options for first- and second-line tre......

Single-cell DNA methylome analysis of circulating tumor cells

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (3)

Objective: Previous investigations of circulating tumor cells (CTCs) have mainly focused on their genomic or transcriptomic features, leaving their ep......

Phase 1 studies comparing safety, tolerability, pharmacokinetics and pharmacodynamics of HLX01 (a rituximab biosimilar) to reference rituximab in Chinese patients with CD20-positive B-cell lymphoma

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (3)

Objective: This study aimed to compare the pharmacokinetic, pharmacodynamic and safety profiles of HLX01 (a rituximab biosimilar) and reference rituxi......

Novel therapies targeting hypoxia mechanism to treat pancreatic cancer

期刊: CHINESE JOURNAL OF CANCER RESEARCH, 2021; 33 (2)

Pancreatic cancer (PC) is one of the deadliest malignancies. The high mortality rate of PC largely results from delayed diagnosis and early metastasis......

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