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Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (1)

To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to ......

A high stable pH-temperature dual-sensitive liposome for tuning anticancer drug release

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (2)

In order to improve the targeting and availability of liposomes to cancer cells, the temperature sensitivity of 1, 2-Dipalmitoyl-sn-glycero-3-phosphoc......

An aurora of natural products-based drug discovery is coming

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (2)

Natural products (NPs), a nature's reservoir possessing enormous structural and functional diversity far beyond the current ability of chemical synthe......

Toward fine-tuned metabolic networks in industrial microorganisms

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (2)

There are numerous microorganisms in nature capable of synthesizing diverse useful compounds; however, these natural microorganisms are generally inef......

Coordinated regulation for nature products discovery and overproduction in Streptomyces

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (2)

Streptomyces is an important treasure trove for natural products discovery. In recent years, many scientists focused on the genetic modification and m......

Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (2)

The lincosamide family antibiotic lincomycin is a widely used antibacterial pharmaceutical generated by Streptomyces lincolnensis, and the high-yield ......

Prudently conduct the engineering and synthesis of the SARS-CoV-2 virus

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (2)

In response to the outbreak of COVID-19 that has been sweeping the world, scientists reconstructed the SARS-CoV-2 rapidly using a synthetic genomics p......

Physical stimuli-responsive cell-free protein synthesis

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (4)

Cell-free protein synthesis has been developed as a critical platform in synthetic biology. Unlike the cell-based synthesis system, cell-free system a......

Applications of phage-derived RNA-based technologies in synthetic biology

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (4)

As the most abundant biological entities with incredible diversity, bacteriophages (also known as phages) have been recognized as an important source ......

Converting Escherichia coli MG1655 into a chemical overproducer through inactivating defense system against exogenous DNA

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (4)

Escherichia coli strain K-12 MG1655 has been proposed as an appropriate host strain for industrial production. However, the direct application of this......

Enhancing single-cell hyaluronic acid biosynthesis by microbial morphology engineering

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (4)

Microbial morphology engineering is a novel approach for cell factory to improve the titer of target product in bio-manufacture. Hyaluronic acid (HA),......

Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (4)

Electroactive bacteria could perform bi-directional extracellular electron transfer (EET) to exchange electrons and energy with extracellular environm......

CRISPR base editing and prime editing: DSB and template-free editing systems for bacteria and plants

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020; 5 (4)

CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR associated) has been extensively exploited as a genetic tool for genome e......

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