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Access to the C2 C-H olefination, alkylation and deuteration of indoles by rhodium(iii) catalysis: an opportunity for diverse syntheses

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (12)

A concise approach for the synthesis of structurally diverse indoles enabled by Rh-III-catalyzed switchable C2 C-H olefination and alkylation of N-qui......

Catalytic asymmetric synthesis of monofluoroalkenes and gem-difluoroalkenes: advances and perspectives

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (10)

Driven by the continuous demand for optically active fluoro-containing molecules from the chemical society, the field of fluorochemistry has emerged a......

Merging CF3SO2Na photocatalysis with palladium catalysis to enable decarboxylative cross-coupling for the synthesis of aromatic ketones at room temperature

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (13)

A CF3SO2Na/Pd(OAc)(2) co-catalysis strategy was developed to produce aryl ketones via visible-light-induced decarboxylative cross-coupling of alpha-ox......

Photoinduced triiodide-mediated [3+2] cycloaddition of N-tosyl aziridines and alkenes

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (10)

A metal-free photoinduced triiodide-mediated [3 + 2] cycloaddition of N-Ts aziridines with alkenes is described herein. This operationally simple prot......

Enantioselective organocatalytic sequential Michael-cyclization of functionalized nitroalkanes to 2-hydroxycinnamaldehydes: synthesis of benzofused dioxa[3.3.1] and oxa[4.3.1] methylene-bridged compounds

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (15)

An organocatalytic enantioselective conjugate addition-initiated reaction sequence of 2-hydroxycinnamaldehydes with various functionalized nitroalkane......

Copper-catalyzed 1,6-conjugate addition of para-quinone methides with diborylmethane

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (16)

Presented herein is the first 1,6-conjugate addition of diborylmethane, which is promoted by a simple and inexpensive copper catalytic system. This me......

Intramolecular difunctionalization of methylenecyclopropanes tethered with carboxylic acid by visible-light photoredox catalysis

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (16)

We have developed a visible-light photoredox catalyzed intramolecular difunctionalization of MCPs to access spiro[cyclopropane-1,2-indan]one from easi......

Highly regio- and stereo-selective heterogeneous 1,3-diyne hydrosilylation controlled by a nickel-metalated porous organic polymer

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (17)

A porous organic polymer (POL-xantphos) was synthesized and employed as a heterogeneous ligand for nickel catalyzed highly regio- and stereo-selective......

Umpolung of donor-acceptor cyclopropanes via N-heterocyclic carbene organic catalysis

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (18)

A carbene-catalyzed formal umpolung of donor-acceptor (D-A) cyclopropanes is disclosed. The cyclopropane moiety is connected to an acetyl aldehyde tha......

Dirhodium(ii)-catalyzed diamination reaction via a free radical pathway

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (18)

Unlike C-N bond formation with classical dirhodium(ii)-nitrenoids as the key intermediate, dirhodium(ii)-catalyzed 1,2- and 1,3-diamination reactions ......

Access to thiazoles via [3+2] cycloaddition of 1,2,3-thiadiazoles with isonitriles dagger

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (12)

Sulfur-containing heterocycles are important structural units that could be commonly found in pharmaceuticals and functional molecules. Herein, we rep......

Palladium-catalyzed [2+2+1] annulation: access to chromone fused cyclopentanones with cyclopropenone as the CO source

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (12)

Herein we report a palladium-catalyzed [2 + 2 + 1] annulation among 3-iodochromones, bridged olefins, and cyclopropenone, giving a variety of chromone......

Formal total synthesis of (+/-)-7-deoxycylindrospermopsin and its 8-epi isomer

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (13)

7-Deoxycylindrospermopsin is a member of cylindrospermopsin marine alkaloid containing a cyclic guanidine group. Herein, we present a concise formal t......

Indolizine synthesis via radical cyclization and demethylation of sulfoxonium ylides and 2-(pyridin-2-yl)acetate derivatives

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (15)

A novel radical cross-coupling/cyclization of 2-(pyridin-2-yl)acetate derivatives and sulfoxonium ylides is developed, which provides a straightforwar......

Symmetric cytotoxic trimeric and dimeric indole alkaloids isolated from Bousigonia angustifolia dagger

期刊: ORGANIC CHEMISTRY FRONTIERS, 2021; 8 (11)

A symmetric monoterpenoid indole alkaloid trimer, bousangustine A, is reported for the first time, as well as the dimeric alkaloids bousangustines B a......

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