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Preparation of camptothecin micelles self-assembled from disodium glycyrrhizin and tannic acid with enhanced antitumor activity

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 164 ()

Natural compounds as carriers for hydrophobic drugs have been increasingly used in drug delivery systems. In this study, disodium glycyrrhizin (Na2GA)......

Exploring the possible targeting strategies of liposomes against methicillin-resistant Staphylococcus aureus (MRSA)

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 165 ()

Multi antibiotic-resistant bacterial infections are on the rise due to the overuse of antibiotics. Methicillin-resistant Staphylococcus aureus (MRSA) ......

"Felodipine-indomethacin" co-amorphous supersaturating drug delivery systems: "Spring-parachute" process, stability, in vivo bioavailability, and underlying molecular mechanisms

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 166 ()

Amorphous solid dispersions (ASD) are one of most commonly used supersaturating drug delivery systems (SDDS) to formulate insoluble active pharmaceuti......

Cisplatin-induced ototoxicity: Updates on molecular mechanisms and otoprotective strategies

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 163 ()

Cisplatin is a highly effective antitumor drug generally used in the treatment of solid malignant tumors. However, cisplatin causes severe side effect......

Screening of metabolites in the treatment of liver cancer xenografts HepG2/ ADR by psoralen-loaded lipid nanoparticles

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 165 ()

Objective: Our study aimed to find potential biomarkers for drug resistance in liver cancer cells using metabolomics and further to evaluate the poten......

Synthesis and characterization of osmotic pump capsules containing polyoxyethylene and pH modifier to control the release of nifedipine

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 163 ()

The aim of this study was to formulate osmotic pump capsules (OPCs) to control the release of nifedipine (NP). NP solid dispersion was prepared by sol......

Emerging strategies against tumor-associated fibroblast for improved the penetration of nanoparticle into desmoplastic tumor

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 165 ()

The therapeutic effect of nanoparticles is limited in solid tumors, especially desmoplastic tumors, because the tumor matrix hinders the delivery of n......

One-step preparation of photoclick method for embolic microsphere synthesis and assessment for transcatheter arterial embolization

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 166 ()

Vascular embolization is a well-known therapeutic treatment against hepatocellular carcinoma. However, existing embolic agents require complex synthes......

Novel Fe(III)-Polybasic acid coordination polymer nanoparticles with targeted retention for photothermal and chemodynamic therapy of tumor

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 165 ()

The development of Fe-coordination polymer-based nanoparticles, with safe and high anti-tumor effects, for the treatment of tumor is facing challenges......

Improved imiquimod-induced psoriasis like dermatitis using microneedles in mice

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 164 ()

Psoriasis is a chronic inflammatory skin disease, in which the key features are epidermis hyperplasia, hyperkeratinization, leading to low drug absorp......

A small molecule nanodrug consisting of pH-sensitive ortho ester-dasatinib conjugate for cancer therapy

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 163 ()

The main objective of this paper is to develop a self-delivered prodrug system with nanoscale characteristics to enhance the efficacy of tumor therapy......

A review of nanoparticle drug delivery systems responsive to endogenous breast cancer microenvironment

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 166 ()

Breast cancer, as a malignant disease that seriously threatens women's health, urgently needs to be researched to develop effective and safe therapeut......

Phenylboronic acid modified nanoparticles simultaneously target pancreatic cancer and its metastasis and alleviate immunosuppression

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 165 ()

Pancreatic ductal adenocarcinoma is one of the most lethal malignant tumors, its drug resistance, immunosuppression and metastasis makes the tradition......

Chlorogenic acid sustained-release gel for treatment of glioma and hepatocellular carcinoma

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 166 ()

Chlorogenic acid (CGA) may provide an effective and safe option for tumor treatment. However, its application is limited because of short residence ti......

Administration in fed state but not controlled release in the colon increases oral bioavailability of DF030263, a promising drug candidate for chronic lymphocytic leukemia

期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021; 165 ()

For treatment of chronic cancers, the oral administration route is preferred as it provides numerous advantages over other delivery routes. However, t......

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