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Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix

期刊: BRAIN PATHOLOGY, ; ()

Neurovascular dysfunction is a primary or secondary cause in the pathogenesis of several cerebrovascular and neurodegenerative disorders, including st......

Downregulated GPR30 expression in the epileptogenic foci of female patients with focal cortical dysplasia type IIb and tuberous sclerosis complex is correlated with F-18-FDG PET-CT values

期刊: BRAIN PATHOLOGY, 2021; 31 (2)

Focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) are typical causes of developmental delay and refractory epilepsy. G-p......

A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP

期刊: BRAIN PATHOLOGY, 2021; 31 (2)

Polymorphisms in TMEM106B, a gene on chromosome 7p21.3 involved in lysosomal trafficking, correlates to worse neuropathological, and clinical outcomes......

Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome

期刊: BRAIN PATHOLOGY, 2020; 30 (1)

Some mouse models of Down syndrome (DS), including Ts1Cje mice, exhibit impaired prenatal neurogenesis with yet unknown molecular mechanism. To gain i......

Cerebrovascular miRNAs correlate with the clearance of A beta through perivascular route in younger 3xTg-AD mice

期刊: BRAIN PATHOLOGY, 2020; 30 (1)

The "two-hit vascular hypothesis for Alzheimer's disease (AD)" and amyloid-beta (A beta) oligomer hypothesis suggest that impaired soluble A beta olig......

cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading

期刊: BRAIN PATHOLOGY, 2020; 30 (4)

cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recomme......

IL-1 beta/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-synuclein pathology in the olfactory bulb, substantia nigra and striatum

期刊: BRAIN PATHOLOGY, 2020; 30 (6)

Olfactory dysfunction is one of the early symptoms seen in Parkinson's disease (PD). However, the mechanisms underlying olfactory pathology that impac......

Whole-exome sequencing revealed mutational profiles of giant cell glioblastomas

期刊: BRAIN PATHOLOGY, 2019; 29 (6)

Giant cell glioblastoma (gcGBM) is a rare histological variant of GBM, accounting for about 1% of all GBM. The prognosis is poor generally though gcGB......

JIF:6.16

Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/beta-catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide

期刊: BRAIN PATHOLOGY, 0; ()

Neuroinflammation is thought to play a pivotal role in the pathogenesis of periventricular white matter (PWM) damage (PWMD) induced by neonatal sepsis......

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