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The effect of mild hypothermia plus rutin on the treatment of spinal cord injury and inflammatory factors by repressing TGF-beta/smad pathway

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (3)

Purpose: To probe the mechanism of mild hypothermia combined with rutin in the treatment of spinal cord injury (SCI). Methods: Thirty rats were random......

Beneficial effects of octreotide in alcohol-induced neuropathic pain. Role of H2S, BDNF, TNF-alpha and Nrf2

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (4)

Purpose: To explore the role and molecular mechanisms of neuroprotective effects of octreotide in alcohol-induced neuropathic pain. Methods: Male Wist......

Effects of Rehmannia glutinosa polysaccharides on bone tissue structure and skeletal muscle atrophy in rats with disuse

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (4)

Purpose: To study effects of Rehmannia glutinosa polysaccharides (RGP) on bone tissue structure and skeletal muscle atrophy in rats with disuse. Metho......

Effect of IL-33 on pyroptosis of macrophages in mice with sepsis via NF-kappa B/p38 MAPK signaling pathway

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (5)

Purpose: To demonstrate the effect of IL-33 on the macrophage pyroptosis in mice with sepsis through the NF-kB/p38 MAPK signal pathway. Methods: In to......

Shen-fu injection alleviates acute renal injury by reducing cytokine levels and modulating apoptosis in a porcine hemorrhagic shock model

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (4)

Purpose: Shen-fu injection (SFI) was used to intervene in the resuscitation of porcine hemorrhagic shock (HS) model to study its protective effects on......

Controlled decompression alleviates early brain injury in rabbit intracranial hypertension model by regulating apoptosis/necroptosis

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (4)

Purpose: To evaluate the effects of controlled decompression and rapid decompression, explore the potential mechanism, provide the theoretical basis f......

Study on the effect of the treatment of Periplaneta americana L. extract Ento-B by Dinitrochlorobenzene combined with acetic acid induced UC in rats

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (1)

Purpose: To study the Periplaneta americana L. extract Ento-B on the treatment of chronic ulcerative colitis induced by 2,4-dinitrochlorobenzene and a......

Beneficial role of oleuropein in sepsis-induced myocardial injury. Possible Involvement of GSK-3 beta/NF-kB pathway

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (1)

Purpose: The present study explored the potential therapeutic role of oleuropein in sepsis-induced heart injury along with the role of GSK-3 beta/NF-k......

Liraglutide restores late cardioprotective effects of remote preconditioning in diabetic rats via activation of hydrogen sulfide and nuclear factor erythroid 2-related factor 2 signaling pathway

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (2)

Purpose: The present study explored the influence of liraglutide on remote preconditioning-mediated cardioprotection in diabetes mellitus along with t......

Protective effects of ischemic postconditioning on skeletal muscle following crush syndrome in the rat

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (7)

Purpose: To investigate the effect of ischemic postconditioning (IPostC) on skeletal muscle and its optimal protocol. Methods: This article is about a......

Ferulic acid improves motor function induced by spinal cord injury in rats via inhibiting neuroinflammation and apoptosis

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (7)

Purpose: To investigate the effect of ferulic acid (FA) on spinal cord injury (SCI)-induced motor dysfunction and to explore the possible pharmacologi......

Inhibition of CXCR2 alleviates the development of abdominal aortic aneurysm in Apo E-/- mice

期刊: ACTA CIRURGICA BRASILEIRA, 2021; 36 (1)

Purpose: To investigate the relationship between atherosclerotic abdominal aortic aneurysm (AAA) and CXC chemokine receptor type 2 (CXCR2). Methods: M......

Glutamine protects intestine against ischemia-reperfusion injury by alleviating endoplasmic reticulum stress induced apoptosis in rats

期刊: ACTA CIRURGICA BRASILEIRA, 2020; 35 (1)

Purpose: Glutamine, as an essential part of enteral nutrition and parenteral nutrition agent, has been widely recognized to be a kind of important int......

Involvement of HSP90 in ischemic postconditioning-induced cardioprotection by inhibition of the complement system, JNK and inflammation

期刊: ACTA CIRURGICA BRASILEIRA, 2020; 35 (1)

Purpose: To investigate whether heat shock protein 90 (HSP90) is involved in complement regulation in ischemic postconditioning (IPC). Methods: The le......

Role of adiponectin in diabetes myocardial ischemia-reperfusion injury and ischemic postconditioning

期刊: ACTA CIRURGICA BRASILEIRA, 2020; 35 (1)

Purpose: Patients with diabetes are vulnerable to myocardial I/R (ischaemia/reperfusion) injury, but are not responsive to IPO (ischaemic post-conditi......

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