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Transplantation of Neural Progenitor Cells Generated from Human Urine Epithelial Cell-Derived Induced Pluripotent Stem Cells Improves Neurological Functions in Rats with Stroke

期刊: DISCOVERY MEDICINE, 2020; 29 (156)

As a potentially unlimited autologous cell source, induced pluripotent stem cells (iPSCs) provide a needed option for the application of iPSC-derived ......

Long Non-coding RNAs Engender Drug Resistance to Different Subtypes of Treatments of Breast Cancers and May Provide a "Next Generation" Therapy Option

期刊: DISCOVERY MEDICINE, 2020; 29 (156)

The dysfunction of long non-coding RNAs (lncRNAs), without protein-coding potential, has been implicated in drug resistance to treatments in various h......

Antitumor Effects of Icaritin and the Molecular Mechanisms

期刊: DISCOVERY MEDICINE, 2020; 29 (156)

Traditional Chinese Medicine (TCM) has been increasingly studied for antitumor activities. Icaritin, a hydrolytic product of icariin, is an effective ......

Microbial Cell-free DNA in Plasma of Patients with Sepsis: A Potential Diagnostic Methodology

期刊: DISCOVERY MEDICINE, 2020; 29 (157)

Sepsis is a life-threatening clinical condition demanding accurate and rapid diagnosis of the culprit pathogen, thereby to improve prognosis. Pathogen......

Serum HBV RNA Levels Predict Significant Liver Fibrosis in Patients with Chronic HBV Infection

期刊: DISCOVERY MEDICINE, 2020; 29 (157)

Background and Aim. Recently, several studies demonstrated that serum HBV RNA levels were associated with liver disease progression in patients with c......

Growth Arrest or Drug Target Inactivity Is Not Sufficient for Persister Formation in E. coli

期刊: DISCOVERY MEDICINE, 2020; 29 (157)

Persisters are a subpopulation of slow-growing or nondividing cells that are tolerant to antibiotics and are thought to be involved in persistent infe......

DNA N-6-methyladenine Increased in Human Esophageal Squamous Cell Carcinoma

期刊: DISCOVERY MEDICINE, 2020; 29 (157)

Esophageal cancer is one of the most common malignancies worldwide. DNA N-6-methyladenine (6mA) has been well-studied in prokaryotes, while the distri......

Clinical Management of Sepsis Resulting from Infections Including COVID-19

期刊: DISCOVERY MEDICINE, 2020; 29 (158)

Sepsis is an important disorder in intensive care medicine, and the emphasis is not on infections but the imbalance in body reactions and life-threate......

Production of Aptamers by Cell-SELEX and Their Applications in Cancer Biomarker Identification

期刊: DISCOVERY MEDICINE, 2020; 29 (158)

Cancer is a major cause of disease-related deaths worldwide, and early diagnosis involving detecting biomarkers of tumors can improve the cure rate an......

COVID-19: the Novel Coronavirus Disease and Its Manifestations and Management in Ophthalmology

期刊: DISCOVERY MEDICINE, 2020; 29 (158)

Coronavirus disease 2019 (COVID-19), a newly identified acute respiratory disease caused by a strain of novel coronavirus (SARS-CoV-2), has become a w......

PARP1 Is Upregulated by Hyperglycemia Via N6-methyladenosine Modification and Promotes Diabetic Retinopathy

期刊: DISCOVERY MEDICINE, 2022; 34 (172)

Poly (ADP-ribose) polymerase 1 (PARP1) plays an irreplaceablerole in the progression of diabetic retinopathy (DR). The m6A methylation in mRNA control......

JIF:3.667

The Independent Association Between Age and Serum Cholesterol Levels in Patients with Familial Hypercholesterolemia

期刊: DISCOVERY MEDICINE, 2022; 34 (173)

Background: Studies have suggested that age and the serum total cholesterol (TC) concentration are independent risk factors for cardiovascular disease......

JIF:3.667

Bacillus Calmette-Guerin for the Treatment of Non-muscle Invasive Bladder Cancer: History and Current Status

期刊: DISCOVERY MEDICINE, 2022; 33 (169)

In the past decades, the bacillus Calmette-Guerin (BCG) treatment for non-muscle invasive bladder cancer, especially for intermediate and high-risk gr......

JIF:3.667

Oxidative Stress-Responsive Small Extracellular Vesicles and MicroRNAs in Age-related Macular Degeneration: Biomarkers and Therapeutic Tools

期刊: DISCOVERY MEDICINE, 2022; 34 (171)

Age-related macular degeneration (AMD) is the main cause of blurred vision, and oxidative stress is a leading risk factor for AMD pathology. Small ext......

JIF:3.667

Metabolic Bariatric Surgery in the Treatment of Obesity Complicated with Hypertension: Mechanistic Insight

期刊: DISCOVERY MEDICINE, 2022; 33 (170)

The increase of dietary fat energy supply ratio has led to a gradual increase in obesity, and the risk of hypertension in patients with obesity is muc......

JIF:3.667

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