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CNG channel structure, function, and gating: a tale of conformational flexibility

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (9)

Cyclic nucleotide-gated (CNG) channels are key to the signal transduction machinery of certain sensory modalities both in vertebrate and invertebrate ......

Myosin light chain 2 marks differentiating ventricular cardiomyocytes derived from human embryonic stem cells

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (7)

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great value for studies of human cardiac development, drug discovery, disease model......

Inhibition of Ca2+-dependent protein kinase C rescues high calcium-induced pro-arrhythmogenic cardiac alternans in rabbit hearts

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (8)

Cardiac alternans closely linked to calcium dysregulation is a crucial risk factor for fatal arrhythmia causing especially sudden death. Calcium overl......

Common and discrete mechanisms underlying chronic pain and itch: peripheral and central sensitization

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (10)

Normally, an obvious antagonism exists between pain and itch. In normal conditions, painful stimuli suppress itch sensation, whereas pain killers ofte......

Importance of evaluating protein glycosylation in pluripotent stem cell-derived cardiomyocytes for research and clinical applications

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (7)

Proper protein glycosylation is critical to normal cardiomyocyte physiology. Aberrant glycosylation can alter protein localization, structure, drug in......

Cell surface markers for immunophenotyping human pluripotent stem cell-derived cardiomyocytes

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (7)

Human pluripotent stem cells (hPSC) self-renew and represent a potentially unlimited source for the production of cardiomyocytes (CMs) suitable for st......

Structure and dynamics of photoreceptor sensory cilia

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (9)

The rod and cone photoreceptor cells of the vertebrate retina have highly specialized structures that enable them to carry out their function of light......

The updated view on induced pluripotent stem cells for cardiovascular precision medicine

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, ; ()

Cardiovascular diseases have consistently been one of the leading causes of mortality, despite investigations by many scientists and clinicians. Anima......

Human pluripotent stem cell-based cardiovascular disease modeling and drug discovery

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, ; ()

Heart diseases are prevalent worldwide and account for the highest mortality than any other illness. Although investment in drug discovery and develop......

MicroRNA-1246 regulates proliferation, invasion, and differentiation in human vascular smooth muscle cells by targeting cystic fibrosis transmembrane conductance regulator (CFTR)

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (2)

MicroRNA (miRNA) plays a key role in the proliferation and invasion of vascular smooth muscle cells (VSMCs). However, the role and underlying mechanis......

Decreased KLHL3 expression is involved in the activation of WNK-OSR1/SPAK-NCC cascade in type 1 diabetic mice

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (2)

Familial hyperkalemic hypertension (FHHt; also called pseudohypoaldosteronism type II) is a hereditary hypertensive disease which can be caused by mut......

A novel mutation in KCNH2 yields loss-of-function of hERG potassium channel in long QT syndrome 2

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (2)

Mutations in hERG (human ether-a-go-go-related gene) potassium channel are closely associated with long QT syndromes. By direct Sanger sequencing, we ......

Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2021; 473 (3)

Hibernation allows animals to enter an energy conserving state to survive severe drops in external temperatures and a shortage of food. It has been ob......

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