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Validation of Non-invasive Fibrosis Scores for Predicting Advanced Fibrosis in Metabolic-associated Fatty Liver Disease

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (4)

Background and Aims: Metabolic-associated fatty liver disease (MAFLD) is a newly proposed terminology from 2020; yet, the applicability of conventiona......

A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (5)

Background and Aims: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the incidence and mortality rates are increasing. Give......

Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (2)

Background and Aims: Numerous studies have explored the important role of N6-methyladenosine (m(6)A) in cancer. Nonetheless, the interaction between m......

Transplantation of Mesenchymal Stem Cells Attenuates Acute Liver Failure in Mice via an Interleukin-4-dependent Switch to the M2 Macrophage Anti-inflammatory Phenotype

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (4)

Background and Aims: Transplantation of mesenchymal stem cells (MSCs) derived from bone marrow (BM) is an alternative treatment of acute liver failure......

Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (2)

Background and Aims: We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver......

KRT17 Promotes the Activation of HSCs via EMT in Liver Fibrosis

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (2)

Background and Aims: Although activation of hepatic stellate cells (HSCs) plays a central role in the development of liver fibrosis, the mechanism und......

FOXO1 Alleviates Liver Ischemia-reperfusion Injury by Regulating the Th17/Treg Ratio through the AKT/Stat3/FOXO1 Pathway

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (6)

Background and Aims: Hepatic ischemic reperfusion injury (IRI) occurring during surgery seriously affects patient prognosis. The specific mechanism of......

Interaction of SAMM50-rs738491, PARVB-rs5764455 and PNPLA3-rs738409 Increases Susceptibility to Nonalcoholic Steatohepatitis

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (2)

Background and Aims: Previous studies have reported that the single nucleotide polymorphisms (SNPs) of SAMM50-rs738491, PARVB-rs5764455 and PNPLA3-rs7......

A Prognostic Nomogram for Hepatocellular Carcinoma Based on Wound Healing and Immune Checkpoint Genes

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (5)

Background and Aims: Wound healing and tumor progression share some common biological features; however, how variations in wound healing patterns affe......

Quzhi Formula Alleviates Nonalcoholic Steatohepatitis by Impairing Hepatocyte Lipid Accumulation and Inflammation via Bip/eIF2 alpha Signaling

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (6)

Background and Aims: The Quzhi formula, a Chinese medicine compound prescription, relieves nonalcoholic steatohepatitis (NASH) symptoms. This study ai......

Development and Validation of a Nomogram for Prediction of the Risk of MAFLD in an Overweight and Obese Population

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (6)

Background and Aims: Metabolic associated fatty liver disease (MAFLD) is a serious condition, and a simple method is needed for practitioners to ident......

HBeAg-negative Patients with Chronic Hepatitis B Virus Infection and Normal Alanine Aminotransferase: Wait or Treat?

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (5)

Alanine aminotransferase (ALT) is a common clinical indicator of liver inflammation. The current Chinese guidelines for the management of chronic hepa......

Complementary Presence of HBV Humoral and T-cell Response Provides Protective Immunity after Neonatal Immunization

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (4)

Background and Aims: Hepatitis B vaccination is the most cost effective way to prevent hepatitis B virus (HBV) infection. Hepatitis B vaccine (HepB) e......

Hepatic Arterioportal Fistulas: A Retrospective Analysis of 97 Cases

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (4)

Background and Aims: Hepatic arterioportal fistulas (HAPFs) are abnormal shunts or aberrant functional connections between the portal venous and the h......

Kruppel-like Factor 13 Promotes HCC Progression by Transcriptional Regulation of HMGCS1-mediated Cholesterol Synthesis

期刊: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022; 10 (6)

Background and Aims: Kruppel-like factor (KLF) has a role in the occurrence, development and metabolism of cancer. We aimed to explore the role and po......

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