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The mechanism research on the anti-liver fibrosis of emodin based on network pharmacology

期刊: IUBMB LIFE, 2021; 73 (9)

Aims This study was designated to illustrate the underlying mechanisms of emodin anti-liver fibrosis via network pharmacology and experiment. Methods ......

CPEB1 enhances erastin-induced ferroptosis in gastric cancer cells by suppressing twist1 expression

期刊: IUBMB LIFE, 2021; 73 (9)

The induction of ferroptosis is considered a new strategy for cancer treatment. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is a pos......

HOXA5 induces M2 macrophage polarization to attenuate carotid atherosclerosis by activating MED1

期刊: IUBMB LIFE, 2021; 73 (9)

Macrophage polarization is of great importance in the formation of atherosclerotic plaque. Homeobox A5 (HOXA5), one of the homeobox transcription fact......

Circ_0072088 promotes progression of hepatocellular carcinoma by activating JAK2/STAT3 signaling pathway via miR-375

期刊: IUBMB LIFE, 2021; 73 (9)

Circular RNAs feature prominently in cancer development. Nonetheless, the role of circ_0072088 in hepatocellular carcinoma (HCC) remains unclear. GEO ......

SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non-Small cell lung cancer and inhibit tumor progression

期刊: IUBMB LIFE, 2021; 73 (9)

To explore the effect and mechanism of SIRT6 on radiosensitivity and tumor progression of non-small cell lung cancer (NSCLC). qRT-PCR was performed to......

miR-543 in human mesenchymal stem cell-derived exosomes promotes cardiac microvascular endothelial cell angiogenesis after myocardial infarction through COL4A1

期刊: IUBMB LIFE, 2021; 73 (7)

To explore the impact and mechanism of human mesenchymal stem cells (hMSCs) on the angiogenesis of cardiac microvascular endothelial cells (CMECs) aft......

Urinary proteomic analysis to identify a potential protein biomarker panel for the diagnosis of tuberculosis

期刊: IUBMB LIFE, 2021; 73 (8)

Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the primary causes of death worldwide. Rapid and accurate diagnosis of TB is o......

The effect of Chinese herbal medicine on digestive system and liver functions should not be neglected in COVID-19: An updated systematic review and meta-analysis

期刊: IUBMB LIFE, 2021; 73 (5)

Gastrointestinal symptoms and liver injury are common in patients with coronavirus disease 2019 (COVID-19). However, profiles of different pharmaceuti......

Epigenetic transcripts of LINC01311 and hsa-miR-146a-5p regulate neural development in a cellular model of Alzheimer's disease

期刊: IUBMB LIFE, 2021; 73 (7)

Emerging evidence has shown that Long noncoding RNAs (LncRNAs) are aberrantly expressed and functionally involved in the development of neurodegenerat......

lncRNA XIST knockdown suppresses hypoxia/reoxygenation (H/R)-induced apoptosis of H9C2 cells by regulating miR-545-3p/G3BP2

期刊: IUBMB LIFE, 2021; 73 (9)

This study was aimed at determining the roles and functions of lncRNA XIST/miR-545-3p/G3BP2 axis during hypoxia/reoxygenation (H/R)-induced H9C2 cell ......

Placenta-specific protein 1 promotes cell proliferation via the AKT/GSK-3 beta/cyclin D1 signaling pathway in gastric cancer

期刊: IUBMB LIFE, 2021; 73 (9)

Gastric cancer is a malignant tumor with a poor prognosis. Therefore, it is important to search for molecules that play a vital role in the developmen......

Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma

期刊: IUBMB LIFE, ; ()

The epigenetic abnormality is believed as a major driver for cancer initiation. Histone modification plays a vital role in tumor formation and progres......

MicroRNA-216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer-A transcriptome analysis

期刊: IUBMB LIFE, ; ()

Gene expression profiling has been broadly performed in the field of cancer research. This study aims to explore the key gene regulatory network and f......

Combined effect of chrysin and apigenin on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38-MAPK/AKT pathway

期刊: IUBMB LIFE, ; ()

Either apigenin or chrysin alone has been found to exert anti-inflammatory and tumor suppressive effect. However, the combined effect of apigenin and ......

Iron accumulation regulates osteoblast apoptosis through lncRNA XIST/miR-758-3p/caspase 3 axis leading to osteoporosis

期刊: IUBMB LIFE, 2021; 73 (2)

Postmenopausal osteoporosis (PMOP) is mainly caused by multiple factors. Recent studies have suggested that iron accumulation (IA) was closely related......

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