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The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background Assessment of immune function is of key importance in recognition of disease or healthy status, which still faces challenge in clinical pra......

JIF:2.769

Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background Statins have been widely used to prevent cardiovascular disease in middle-aged and elderly populations; however, the effect of long-term tr......

JIF:2.769

Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background Grass carp are an important farmed fish in China that are infected by many pathogens, especially grass carp reovirus (GCRV). Notably, grass......

JIF:2.769

Phenotypic and functional alterations of monocyte subsets with aging

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background: It has been widely accepted that monocytes are one of the central mediators contributing to inflammaging. However, it remains unclear whet......

JIF:2.769

Knockdown of lncRNA BDNF-AS inhibited the progression of multiple myeloma by targeting the miR-125a/b-5p-BCL2 axis

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Purpose This study aimed to explore the role of long non-coding RNA (lncRNA) BDNF-AS in the progression of multiple myeloma (MM). Methods The expressi......

JIF:2.769

Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background COVID-19 patients may experience cytokine storm when human immune system produces excessive cytokines/chemokines. However, it remains uncle......

JIF:2.769

The diseased kidney: aging and senescent immunology

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily characterized by a reduction in......

JIF:2.769

Excessive IL-15 promotes cytotoxic CD4+CD28-T cell-mediated renal injury in lupus nephritis

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background Patients with systemic lupus erythematosus (SLE) are highly susceptible to infection and cardiovascular events, suggesting that chronic ant......

JIF:2.769

The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of the immune system suggests......

JIF:2.769

Different phenotypes of microglia in animal models of Alzheimer disease

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Microglia are immune-competent cells that are critically involved in maintaining normal brain function. A prominent characteristic of Alzheimer diseas......

JIF:2.769

Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are readily avail......

JIF:2.769

Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background The immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during norma......

JIF:2.769

C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background Systemic inflammation has been linked to diseases and frailty. However, little is known about the effect of systemic inflammation on frailt......

JIF:2.769

Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study

期刊: IMMUNITY & AGEING, 2022; 19 (1)

Background Depression is considered to be an immune-related disease; however, previous studies have focused on inflammatory factors, and there is no c......

JIF:2.769

Analysis of the heterogeneity of the BCR H-CDR3 repertoire in the bone marrow and spleen of 3-, 12-, and 20-month old mice

期刊: IMMUNITY & AGEING, 2021; 18 (1)

The number of central and peripheral B cells and their responsiveness are decreased in aged mice. The diversity of mice central and peripheral B cell ......

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