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Studies on effect of Tongfengxiaofang in HUM model mice using a UPLC-ESI-Q-TOF/MS metabolomic approach

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (8)

Hyperuricemia (HUM) is a major risk factor for the development of gout. The traditional Chinese medicine (TCM) complex prescription Tongfengxiaofang (......

Development, validation, and application of a simple UPLC-MS/MS method for simultaneous quantification of five traditional antipsychotics in human plasma

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (9)

A UPLC-MS/MS method was developed to determine the levels of five traditional antipsychotics (APs) (chlorprothixene, perphenazine, fluphenazine, thior......

Comparative analysis of excretion of six major compounds of Polygonum orientale L. extract in urine, feces and bile under physiological and myocardial ischemia conditions in rats using UPLC-MS/MS

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (10)

Polygonum orientale L. is a traditional Chinese medicine having extensive pharmacological activities including antimyocardial ischemia (MI) injury pro......

Evaluation of the effects of notoginseng total saponins (NS), safflower total flavonoids (SF), and the combination of NS and SF (CNS) on the activities of cytochrome P450 enzymes using a cocktail method in rats

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (10)

Notoginseng total saponins (NS), safflower total flavonoids (SF), and the combination of NS and SF, namely CNS, are used for the treatment of cardiova......

Pharmacokinetic comparisons of six steroid saponins in rat plasma following oral administration of crude and stir-fried Fructus Tribuli extracts by UHPLC-MS/MS

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (10)

Modern pharmacological studies have shown that Fructus Tribuli can improve sexual function and treat cardiovascular diseases. In this study, we focuse......

Orbitrap-MS-based untargeted metabolomics study on the therapeutic effect of colchicine on myocardial infarction

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (9)

Myocardial infarction (MI) is one of the most common causes of death worldwide. A metabolomic approach based on an ultra-high performance liquid chrom......

Pharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (10)

A sensitive gas chromatography-mass spectroscopy method was established for the determination of cantharidin (CTD) in rat plasma and liver homogenates......

Pharmacokinetic characteristics of hydroxysafflor yellow A in normal and diabetic cardiomyopathy mice

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (10)

Hydroxysafflor yellow A (HSYA), a major active water-soluble component in Corthomus tinctorius L, is considered a potential antioxidant with protectiv......

Polycyclic aromatic hydrocarbons residues and the carcinogenic risk assessment to pregnant women in Nantong, China using QuEChERS method and HPLC-A pilot case study

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (8)

A high-performance liquid chromatographic method with a modified QuEChERS extraction for the determination of polycyclic aromatic hydrocarbons (PAHs) ......

A rapid LC-MS/MS method for simultaneous determination of berberine and irbesartan in rat plasma: Application to the drug-drug pharmacokinetic interaction study after oral administration in rats

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (9)

A sensitive, reproducible, and specific liquid chromatography tandem mass spectrometry method was developed and validated to simultaneously determine ......

High-resolution mass spectrometry-based methodology for the identification of the metabolites of pterostilbene produced by rat, dog and human hepatocytes

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (9)

Pterostilbene, a natural bibenzjyl compound, has been demonstrated to have pleiotropic anticancer effects against a variety of cancer types. The aim o......

Pharmacokinetics, bioavailability and metabolism of CC-92480 in rat by liquid chromatography combined with electrospray ionization tandem mass spectrometry

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (9)

CC-92480 is a cereblon E3 ubiquitin ligase modulating drug with potent antimyeloma activity. In this study, we developed a sensitive UHPLC-MS/MS metho......

Development of an HPLC-MS method for the determination of four terpene trilactones in Ginkgo biloba leaf extract via quality by design

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (10)

Previously reported HPLC-evaporative light scattering detection methods for terpene trilactone determination in Ginkgo biloba leaf extract (EGBL) have......

Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (10)

Peiyuan Tongnao capsule (PTC) plays an important role in clinical application due to its excellent curative efficacy in the treatment of ischemic stro......

Comparative pharmacokinetics study of six effective components between two dosage forms of Qixue-Shuangbu Prescription in rats by UPLC-MS/MS

期刊： BIOMEDICAL CHROMATOGRAPHY, 2021; 35 (10)

Qixue-Shuangbu Prescription (QSP) is an efficacious prescription for treating heart failure, myocardial ischemia and other diseases. It is composed of......

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