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Essential oil from Euphorbia esula inhibits proliferation and induces apoptosis in HepG2 cells via mitochondrial dysfunction

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

Hepatocellular carcinoma is one of the most prevalent malignancies and a leading cause of cancer-related mortality worldwide. However, the therapies t......

In vivo inhibitory effect of suberoylanilide hydroxamic acid combined with sorafenib on human hepatocellular carcinoma cells

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

The present study aimed to investigate the in vivo inhibitory effect of histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) combined ......

Esculetin as bioactive marker: towards a rational scientific approach for the treatment of hyperuricemia using Traditional Chinese Medicine

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

Traditional Chinese Herbal Medicine has been used to prevent and cure disease in China for thousands of years and has gained global interest in recent......

Biological evaluation of 2,3-dioxoindolin-N-phenylacetamide derivatives as potent CDC25B and PTP1B phosphatase inhibitors

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

A series of 2,3-dioxoindolin-N-phenylacetamide derivatives was evaluated for inhibitory activity against CDC25B and PTP1B enzymes. Most of the derivat......

PAK6: a potential anti-cancer target

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs re......

Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activi......

The effect of food intake on the pk of rhein released from diacerein

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

Diacerein is a symptomatic slow-acting drug used for treating osteoarthritis. This drug is completely metabolized into the active metabolite rhein bef......

Polymeric emulgel carrying Cinnamomum tamala extract: promising delivery system for potential topical applications

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

Currently, the use of natural compounds obtained from plants tremendously increased due to their promising therapeutic properties. The aim of this stu......

Exploring the shared genes of hypertension, diabetes and hyperlipidemia based on microarray

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

Given their relationship with metabolic syndrome and systematic inflammatory diseases, the pathogenesis of hypertension, hyperglycemia, and hyperlipid......

Enzyme inhibition and antibacterial potential of 4-Hydroxycoumarin derivatives

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

The 4-Hydroxycoumarin derivatives are known to show a broad spectrum of pharmacological applications. In this paper we are reporting the synthesis of ......

Nesiritide protects endothelial function after balloon-induced trauma in the iliac artery in rabbits

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

To assess the effect of nesiritide on the endothelial function of iliac arteries following endothelia trauma. Right iliac artery trauma was created wi......

Influence of isoniazid on T lymphocytes, cytokines, and macrophages in rats

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020; 56 ()

T lymphocytes, cytokines, and macrophages play important roles in the clearance of Mycobacterium tuberculosis (Mtb) by the immune system. This study a......

Design and evaluation of rhubarb total free anthraquinones oral colon-specific drug delivery granules to improve the purgative effect

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019; 55 ()

Rhubarb is commonly used as a cathartic in Asian countries. However, researchers have devotedextensive concerns to the quality control and safety of r......

JIF:0.51

Curcumin combining with si-MALAT1 inhibits the invasion and migration of colon cancer SW480 cells

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019; 55 ()

To study the effect of small interfering RNA targeting metastasis-associated lung adenocarcinoma transcript) (si-MALAT1) combining with curcumin on th......

JIF:0.51

Protective effects of salidroside on chronic heart failure in rats and the underlying mechanisms

期刊: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019; 55 ()

The present study aimed to investigate the protective effects of salidroside on chronic heart failure (CHF) in rats and to explore the underlying mech......

JIF:0.51

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