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Characterization of tea tree oil nanoemulsion and its acute and subchronic toxicity

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 124 ()

Tea tree oil (TTO) is a popular topical use to treat skin infections. However, its poor aqueous solubility and stability have substantially limited it......

Experimental study for the establishment of a chemotherapy-induced ovarian insufficiency model in rats by using cyclophosphamide combined with busulfan

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 122 ()

With an improvement in the survival rate of cancer patients, chemotherapy-induced premature ovarian insufficiency (POI) is increasingly affecting the ......

Assessment of the toxicity and toxicokinetics of the novel potent tropomyosin receptor kinase (Trk) inhibitor LPM4870108 in rhesus monkeys

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 122 ()

LPM4870108 is a tropomyosin receptor kinase (Trk) inhibitor that is currently under consideration for human clinical trials. We characterized the toxi......

Fertility and early embryonic development toxicity assessment of naringin in Sprague-Dawley rats

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 123 ()

Naringin is a dihydroflavonoid abundantly existed in grapefruit and related citrus species. The double directional adjusting function of estrogenic an......

Support vector machine-based model for toxicity of organic compounds against fish

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 123 ()

Predicting the toxicity of chemicals to various fish species through chemometric approach is crucial for ecotoxicological assessment of existing as we......

Subchronic oral toxicity study of rhubarb extract in Sprague-Dawley rats

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 123 ()

Objective: The study was primarily used to evaluate subchronic oral toxicity of rhubarb extract. Methods: The rhubarb extract was orally administered ......

Safety evaluation of BPL9K-4 rice in a subchronic rodent feeding study

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 123 ()

In the present study, a new genetically modified rice producing phytase-lactoferricin fusion protein, BPL9K-4, was evaluated for safety in a 90-day ra......

Pharmacokinetics of cyadox and its main metabolites in rats, pigs, chickens, and carps following oral administration at three dosage

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 124 ()

Cyadox (CYA), a 1,4-dioxide quinoxaline, is a safe and effective antibacterial agent with potential use in foodproducing animals. The aim of this stud......

Toxicological evaluation of S. involucrata culture: Acute, 90-day subchronic and genotoxicity studies

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 124 ()

Saussurea involucrata is an endangered plant that is used in traditional Chinese medicine. Through the use of plant cell culture techniques, preparati......

Subchronic toxicity study in rats evaluating herbicide-tolerant soybean DAS-68416-4

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 119 ()

A subchronic toxicity study was conducted in Wistar rats to evaluate the potential health effects of genetically modified (GM) herbicide-tolerant soyb......

Aloe gel-base food products: Chemical, toxicological, and regulatory aspects

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2021; 119 ()

Aloe products are increasingly valued as ingredients in food supplements and flavoring agents. In early March 2020, the European Commission drafted a ......

Berberine decreases insulin resistance in a PCOS rats by improving GLUT4: Dual regulation of the PI3K/AKT and MAPK pathways

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2020; 110 ()

Berberine has been found to exhibit an array of pharmacological activities relating to the lowering of blood glucose and the treatment of polycystic o......

Residue analysis of gibberellic acid isomer (iso-GA3) in brewing process and its toxicity evaluation in mice

期刊: REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2020; 110 ()

Gibberellic acid (GA3) is an efficient plant growth regulator, which could speed up barley germination in the brewing industry. However, the residue o......

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