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The role of pulmonary mast cells activation and degranulation in the process of increased pulmonary artery pressure

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (3)

Hypoxia exposure often cause the increases of pulmonary arterial pressure (PAP). Studies reported that mast cells (MCs) participate in pulmonary vascu......

microRNA let-7i-5p aggravates kidney fibrosis via targeting GALNT1

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (2)

Renal fibrosis poses critical health problem. We aimed to investigate role of let-7i-5p in renal fibrosis. In silico reproduction of Mouse Kidney Fibr......

circ_LRIG3 contributes to the progression of hepatocellular carcinoma by elevating RNF38 via sponging miR-449a

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (2)

Circular RNAs (circRNAs) play crucial roles in multiple cancers, including hepatocellular carcinoma (HCC). However, the effects and molecular mechanis......

Silencing of circ-PRKCH protects against lipopolysaccharide (LPS)-evoked chondrocyte damage and extracellular matrix loss by the miR-140-3p/ADAM10 axis

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (2)

Circular RNAs (circRNAs) have been implicated in the pathology of osteoarthritis (OA). Nevertheless, the precise actions of circRNA protein kinase C e......

circ-PTTG1IP/miR-671-5p/TLR4 axis regulates proliferation, migration, invasion and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (3)

Circular RNAs (circRNAs) are related to rheumatoid arthritis (RA) development. However, the function and mechanism of circRNA pituitary tumor-transfor......

Weighted gene correlation network analysis identifies the critical long non-coding RNAs participate in the progression of osteosarcoma

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (3)

This study aimed to identify more biomarkers associated with osteosarcoma progression via lncRNA-mRNA co-expression network. Dataset GSE99671 was down......

Tripartite motif containing 28 (TRIM28) promotes the growth and migration of endometrial carcinoma cells by regulating the AKT/mTOR signaling pathway

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (3)

Although the medical science has been developed for decades, the molecular mechanism of endometrial cancer (EC) is not yet completely clear. Previous ......

Protective effect of Apelin/APJ system on lipopolysaccharide-related cardiac dysfunction

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (3)

At present, the pathogenesis of sepsis-induced myocardial dysfunction (SIMD) is not completely clear and effective treatment measures are lacking. Ape......

circ_0003170 aggravates human hippocampal neuron injuries by regulating the miR-421/CCL2 axis in cells models of epilepsy

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (2)

Emerging evidence proposes that circular RNAs (circRNAs) are involved in epileptogenesis. This study aimed to investigate the role and the function me......

Puerarin protects against human retinal endothelial cells injury induced by high glucose via regulating miR-16-5p/CASP1 axis

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (3)

We aimed to investigate the effects of puerarin on high glucose (HG)-induced human retinal endothelial cells (HRECs) injury. Cells were exposed to pue......

Protective effects of Atractylenolide III on inflammation and oxidative stress in ovalbumin-induced asthma mice and its possible mechanisms

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (2)

Asthma is a complex disorder characterized by chronic inflammation of the airways. We aimed to investigate the role of Atractylenolide III (ATL III) i......

Role of TLR4/NF-kappa B pathway in the damage of acute hypobaric hypoxia to small intestinal mucosa in rats

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (1)

The purpose of this study was to investigate the effect of acute hypobaric hypoxia (HH) exposure on small intestinal mucosa in rats and its underling ......

Enhanced store-operated calcium entry (SOCE) exacerbates motor neurons apoptosis following spinal cord injury

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (1)

Spinal cord injury is pathologically characterized by the loss of motor function caused by neurons apoptosis. Store-operated calcium entry (SOCE) is w......

Identification of differentially expressed genes associated with lung adenocarcinoma via bioinformatics analysis

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2021; 40 (1)

Lung adenocarcinoma (I,UAD) with extremely high morbidity as well as mortality is still in the exploration stage of pathogenesis and treatment. This s......

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