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Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

期刊: CLINICAL IMMUNOLOGY, 2021; 230 ()

Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction in which imbalances in pro-inflammatory and anti-inflamm......

A novel risk score predicts prognosis in melanoma: The combination of three tumor-infiltrating immune cells and four immune-related genes

期刊: CLINICAL IMMUNOLOGY, 2021; 228 ()

Tumor-infiltrating immune cells (TIICs) and immune-related genes (IRGs) of melanoma are associated with prognosis. However, whether the combination of......

Natural killer cells play an important role in virus infection control: Antiviral mechanism, subset expansion and clinical application

期刊: CLINICAL IMMUNOLOGY, 2021; 227 ()

With the global spread of coronavirus disease 2019 (COVID-19), the important role of natural killer (NK) cells in the control of various viral infecti......

Interaction between Ras and Bcl2L12 in B cells suppresses IL-10 expression

期刊: CLINICAL IMMUNOLOGY, 2021; 229 ()

The pathogenesis of recurrent tonsillitis is to be further investigated. B cell-derived interleukin (IL)-10 plays a critical role in immune regulation......

PD-1 signaling pathway in sepsis: Does it have a future?

期刊: CLINICAL IMMUNOLOGY, 2021; 229 ()

Sepsis is characterized by high mortality and poor prognosis and is one of the leading causes of death among patients in the intensive care unit (ICU)......

A novel intracellular nanobody against HPV16 E6 oncoprotein

期刊: CLINICAL IMMUNOLOGY, 2021; 225 ()

Cervical cancer occurs as a result of the persistent infection of high-risk human papillomavirus (HPV). HPV16 oncoproteins E6 and E7 exert different a......

Characterization of follicular T helper cells and donor-specific T helper cells in renal transplant patients with de novo donor-specific HLA-antibodies

期刊: CLINICAL IMMUNOLOGY, 2021; 226 ()

T follicular helper (TFH) cells are a heterogeneous subset of immunocompetent T helper (TH) cells capable of augmenting B cell responses in lymphoid t......

Expression, regulation and clinical significance of B7-H3 on neutrophils in human gastric cancer

期刊: CLINICAL IMMUNOLOGY, 2021; 227 ()

Neutrophils are conspicuous components of gastric cancer (GC) tumors, increasing with tumor progression and poor patient survival. However, the phenot......

Circ_0001103 alleviates IL-1 beta-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375

期刊: CLINICAL IMMUNOLOGY, 2021; 227 ()

Background: Osteoarthritis (OA) is a common inflammatory disease characterized by articular cartilage degeneration and injury. Circular RNAs (circRNAs......

A novel humanized model of rheumatoid arthritis associated lung disease

期刊: CLINICAL IMMUNOLOGY, 2021; 230 ()

Cigarette smoking has been implicated in the pathogenesis of seropositive rheumatoid arthritis (RA), as well as RA-associated lung disease. Fibrotic i......

Identification of 22 novel BTK gene variants in B cell deficiency with hypogammaglobulinemia

期刊: CLINICAL IMMUNOLOGY, 2021; 229 ()

X-linked agammaglobulinemia (XLA) is an inborn error of immunity caused by pathogenic variants in the BTK gene, resulting in impaired B cell different......

Atezolizumab and blockade of LncRNA PVT1 attenuate cisplatin resistant ovarian cancer cells progression synergistically via JAK2/STAT3/PD-L1 pathway

期刊: CLINICAL IMMUNOLOGY, 2021; 227 ()

Objective: To investigate the relationship between lncRNA PVT1(PVT1) level and PD-L1 expression and their functions in cisplatin resistant epithelial ......

Dynamics of HIV reservoir decay and naive CD4 T-cell recovery between immune non-responders and complete responders on long-term antiretroviral treatment

期刊: CLINICAL IMMUNOLOGY, 2021; 229 ()

Background: The dynamics of viral reservoir decay and naive CD4 T-cell recovery between immunological nonresponders (INR) and complete responders (CR)......

Unbalanced expression of membrane-bound and soluble programmed cell death 1 and programmed cell death ligand 1 in systemic juvenile idiopathic arthritis

期刊: CLINICAL IMMUNOLOGY, 2021; 229 ()

The study aimed to investigate the soluble programmed death-1 (sPD-1) and its ligand (sPD-L1) levels in systemic juvenile idiopathic arthritis (sJIA) ......

Integrated analysis of the genomic and transcriptional profile of high-grade gliomas in different age groups

期刊: CLINICAL IMMUNOLOGY, 2021; 226 ()

Background: Age is a powerful prognostic factor of high-grade glioma (HGG). However, the underlying genetic mechanisms of the discrepant prognosis amo......

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