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The prospects of tumor chemosensitivity testing at the single-cell level

期刊: DRUG RESISTANCE UPDATES, 2021; 54 ()

Tumor chemosensitivity testing plays a pivotal role in the optimal selection of chemotherapeutic regimens for cancer patients in a personalized manner......

Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function

期刊: DRUG RESISTANCE UPDATES, 2021; 57 ()

The cytotoxic anti-cancer drugs cisplatin, paclitaxel, doxorubicin, 5-fluorouracil (5-FU), as well as targeted drugs including imatinib, erlotinib, an......

Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance

期刊: DRUG RESISTANCE UPDATES, 2021; 54 ()

ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally and mechanistically distinct substrates against steep con......

Emerging role of autophagy in anti-tumor immunity: Implications for the modulation of immunotherapy resistance

期刊: DRUG RESISTANCE UPDATES, 2021; 56 ()

Immunotherapies such as CAR-T cell transfer and antibody-targeted therapy have produced promising clinical outcomes in patients with advanced and meta......

Targeting the ubiquitin-proteasome pathway to overcome anti-cancer drug resistance

期刊: DRUG RESISTANCE UPDATES, 2020; 48 ()

Drug resistance is a major obstacle in the field of pre-clinical and clinical therapeutics. The development of novel technologies and targeted therapi......

Emerging roles of F-box proteins in cancer drug resistance

期刊: DRUG RESISTANCE UPDATES, 2020; 49 ()

Chemotherapy continues to be a major treatment strategy for various human malignancies. However, the frequent emergence of chemoresistance compromises......

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

期刊: DRUG RESISTANCE UPDATES, 2020; 49 ()

The presence of multidrug resistance (MDR) in malignant tumors is one of the primary causes of treatment failure in cancer chemotherapy. The overexpre......

Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs

期刊: DRUG RESISTANCE UPDATES, 2020; 50 ()

Chemoresistance including intrinsic and acquired anticancer drug resistance continues to be a primary hindrance towards curative cancer treatment. The......

Surmounting cancer drug resistance: New insights from the perspective of N-6-methyladenosine RNA modification

期刊: DRUG RESISTANCE UPDATES, 2020; 53 ()

Despite the development of targeted therapy, drug resistance remains a primary hindrance to curative treatment of various cancers. Among several novel......

Towards the overcoming of anticancer drug resistance mediated by p53 mutations

期刊: DRUG RESISTANCE UPDATES, 2020; 49 ()

Cancer continues to be a leading threat to human health and life. Resistance to anti-cancer drugs is a major impediment towards efficacious cancer tre......

Modulating ROS to overcome multidrug resistance in cancer

期刊: DRUG RESISTANCE UPDATES, 2018; 41 ()

The successful treatment of cancer has significantly improved as a result of targeted therapy and immunotherapy. However, during chemotherapy, cancer ......

JIF:11.71

Epigenetic enzyme mutations as mediators of anti-cancer drug resistance

期刊: DRUG RESISTANCE UPDATES, 2022; 61 ()

Despite the rapid advancement in the introduction of new drugs for cancer therapy, the frequent emergence of drug resistance leads to disease progress......

JIF:17.229

N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells

期刊: DRUG RESISTANCE UPDATES, 2022; 65 ()

Background: Colorectal cancer (CRC) is the 3rd most common cancer worldwide. CircRNAs are promising novel biomarkers for CRC. T regulatory (Treg) cell......

JIF:17.229

Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA

期刊: DRUG RESISTANCE UPDATES, 2022; 65 ()

Aims: This study aimed to identify mechanisms of drug resistance to the combination of vemurafenib, irinotecan, and cetuximab (VIC) in BRAFV600E metas......

JIF:17.229

Cage-modified hypocrellin against multidrug-resistant Candida spp. with unprecedented activity in light-triggered combinational photodynamic therapy

期刊: DRUG RESISTANCE UPDATES, 2022; 65 ()

Infections caused by multidrug-resistant fungi pose a devastating threat to human health worldwide, making new antifungal strategies urgently desired.......

JIF:17.229

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