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The mitochondrial aspartate/glutamate carrier (AGC or Aralar1) isoforms in D. melanogaster: biochemical characterization, gene structure, and evolutionary analysis

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (5)

Background: In man two mitochondrial aspartate/glutamate carrier (AGC) isoforms, known as aralar and citrin, are required to accomplish several metabo......

Role of Gly197 in the structure and function of protein C

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (6)

We previously demonstrated that heterozygous Gly197 to Arg mutation in PROC is associated with venous thrombosis due to the mutation abrogating both z......

alpha 1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (6)

Background: Pancreatic carcinoma is one of the deadliest malignant diseases, in which the increased expression of alpha 1,6-fucosyltransferase (FUT8),......

SUV39H2 controls trophoblast stem cell fate

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (6)

Background: The placenta is formed by the coordinated expansion and differentiation of trophoblast stem (TS) cells along a multi-lineage pathway. Dyna......

The catalytic properties of Thermus thermophilus SG0.5JP17-16 laccase were regulated by the conformational dynamics of pocket loop 6

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (6)

Background: Laccase is one member of the blue multicopper oxidase family. It can catalyze the oxidation of various substrates. The Thermus thermophilu......

Transcriptome analysis of signaling pathways targeted by Ellagic acid in hepatocellular carcinoma cells

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (7)

Background: Ellagic acid (EA) possesses prominent inhibitory activities against various cancers, including hepatocellular carcinoma (HCC). Our recent ......

An atomic perspective on improving daptomycin's activity

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (8)

Background: Recently, through comprehensive medicinal chemistry efforts, we have found a new daptomycin analogue, termed kynomycin, showing enhanced a......

Cross-reactivity of two human IL-6 family cytokines OSM and LIF explored by protein-protein docking and molecular dynamics simulation

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (7)

Background: Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are two important pro-inflammatory cytokines of the interleukin-6 (IL-6) family. T......

A CRISPR/dCas9-assisted system to clone toxic genes in Escherichia coli

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (11)

Background: The cloning of toxic genes in E. coli requires strict regulation of the target genes' leaky expression. Many methods facilitating successf......

Comprehensive analysis of O-glycosylation of amyloid precursor protein (APP) using targeted and multi-fragmentation MS strategy

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (10)

Background: The aberrant proteolytic processing of amyloid precursor protein (APP) into amyloid beta peptide (A beta) in brain is a critical step in t......

Intermolecular insights into allosteric inhibition of histone lysine-specific demethylase 1

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (11)

Background: Histone lysine-specific demethylase 1 (LSD1) has become a potential anticancer target for the novel drug discovery. Recent reports have sh......

O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (8)

Background: Chromatin modifier metastasis-associated protein 1 (MTA1), closely associated with tumor angiogenesis in breast cancer, plays an important......

Identification of connexin43 in diabetic retinopathy and its downregulation by O-GlcNAcylation to inhibit the activation of glial cells

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (10)

Background: Despite advances in the treatments of diabetic complications, proliferative diabetic retinopathy (PDR) still remains a major cause leading......

Human milk derived peptide AOPDM1 attenuates obesity by restricting adipogenic differentiation through MAPK signalling

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (3)

Background: Emerging evidence revealed peptides within breast milk may be an abundant source of potential candidates for metabolism regulation. Our pr......

Blue light induces the nuclear translocation of neuropeptide receptor PAC1-R associated with the up-regulation of PAC1-R its own in reactive oxygen species associated way

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2021; 1865 (6)

PAC1-R is neuropeptide PACAP (pituitary adenylate cyclase activating polypeptide) preferring receptor mediates the antioxidant and cytoprotective effe......

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