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An Effective Brain Imaging Biomarker for AD and aMCI: ALFF in Slow-5 Frequency Band

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (1)

Background: As a potential brain imaging biomarker, amplitude of low frequency fluctuation (ALFF) has been used as a feature to distinguish patients w......

Effects of Gene and Plasma Tau on Cognitive Impairment in Rural Chinese Population

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (1)

Background: Sufficient attention was not paid to the effects of microtubule-associated protein tau (MAPT) and plasma tau protein on cognition. Objecti......

APP/PS1 Gene-Environment Noise Interaction Aggravates AD-like Neuropathology in Hippocampus Via Activation of the VDAC1 Positive Feedback Loop

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (1)

Background: Environmental risk factors, including environmental noise stress, and genetic factors, have been associated with the occurrence and develo......

Apolipoprotein E Gene Revisited: Contribution of Rare Variants to Alzheimer's Disease Susceptibility in Southern Chinese

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (1)

Background: APOE epsilon 4 is the best-known risk factor for late-onset alzheimer's disease (AD). Population studies have demonstrated a relatively lo......

Association of Dietary Habits with Mild Cognitive Impairment among Elderly in Rural Area of North China

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (3)

Background: Recent findings suggest a possible role of diet, particularly nutrient in-takes and dietary patterns, in the prevalence of mild cognitive ......

High Fat Diet Aggravates AD-Related Pathogenic Processes in APP/PS1 Mice

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (4)

Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder and negative lifestyle factors may contribute to its etiopathogenes......

Neural and Retinal Characteristics in Relation to Working Memory in Older Adults with Mild Cognitive Impairment

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (3)

Objective: This study investigated the relationship between neural activities and retinal structures associated with working memory (WM) in older adul......

Codonopsis pilosula Polysaccharides Alleviate A beta(1-40)-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (3)

Background: Alzheimer's disease (AD) is the most common type of dementia and has a complex pathogenesis with no effective treatment. Energy metabolism......

Weight Loss and the Risk of Dementia: A Meta-analysis of Cohort Studies

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (2)

Background: Weight loss is a common phenomenon among the elderly and is identified as an important indicator of health status. Many epidemiology studi......

Risk Assessment During Longitudinal Progression of Cognition in Older Adults: A Community-based Bayesian Networks Model

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (3)

Background: Cognitive dysfunction, particularly in Alzheimer's disease (AD), seriously affects the health and quality of life of older adults. Early d......

Disrupted White Matter Networks from Subjective Memory Impairment to Amnestic Mild Cognitive Impairment

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (1)

Background and Objective: Subjective memory impairment (SMI) is a preclinical stage prior to amnestic mild cognitive impairment (aMCI) along with the ......

Longitudinal Association between White Matter Hyperintensities and White Matter Beta-Amyloid Deposition in Cognitively Unimpaired Elderly

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (1)

Background: White matter (WM) beta-amyloid uptake has been used as a reference region to calculate the cortical standard uptake value ratio (SUVr). Ho......

Clinical Phenotype and Mutation Spectrum of Alzheimer's Disease with Causative Genetic Mutation in a Chinese Cohort

期刊: CURRENT ALZHEIMER RESEARCH, 2021; 18 (3)

Background: Alzheimer's disease with a causative genetic mutation (AD-CGM) is an uncommon form, characterized by a heterogeneous clinical phenotype an......

Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer's Disease Mice

期刊: CURRENT ALZHEIMER RESEARCH, 2020; 17 (1)

Background: Studies have suggested that cognitive impairment in Alzheimer's disease (AD) is associated with dendritic spine loss, especially in the hi......

Disrupted Time-Dependent and Functional Connectivity Brain Network in Alzheimer's Disease: A Resting-State fMRI Study Based on Visibility Graph

期刊: CURRENT ALZHEIMER RESEARCH, 2020; 17 (1)

Background: Alzheimer's Disease (AD) is a progressive neurodegenerative disease with insidious onset, which is difficult to be reversed and cured. The......

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