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Production, Purification and Characterization of 'Iturin A-2' a Lipopeptide with Antitumor Activity from Chinese Sauerkraut Bacterium Bacillus velezensis T701

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021; 27 (3)

This study was done to purify and characterize antitumor lipopeptide from Bacillus strains. Bacillus velezensis strain T701, which was isolated from C......

Rational Molecular Profiling of Receptor-Associated Late Transducer Peptide Selectivity Across Her/Rtk Kinases

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021; 27 (3)

Human epidermal growth factor receptor (Her) family signaling has been linked to diverse cancers, which includes four members: Her1, Her2, Her3 and He......

Protective Effects of Pidotimod Against Salmonella Infections

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021; 27 (3)

Pidotimod has been shown to exhibit immunomodulatory activities and exert protective effects against bacterial infections. This study aimed at evaluat......

Safety Evaluation and Physiological Function of Dietary Balenine Derived From Opah Lampris guttatus on Skeletal Muscle of Mice

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021; 27 (3)

Balenine is one of the endogenous imidazole dipeptides, mainly found in the muscle of marine animals. In this study we focused on the safety evaluatio......

Enhancement of Osteogenic Induction by LL37 Modified with a Collagen-Binding Domain In Vitro and In Vivo

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021; 27 (3)

Bone defect diseases, particularly those induced by inflammation, pose a challenge for the design of ideal drug-loading scaffolds that could facilitat......

A FOXM1-Targeted Peptide Overcomes 5-Fluorouracil Resistance via Modulating ABC Transporters in Liver Cancer HepG2 Cells

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021; 27 (3)

Drug resistance largely limits the efficacy and efficiency of chemotherapeutics, which is a first-line treatment for liver cancer, consequently trigge......

ACHP: A Web Server for Predicting Anti-Cancer Peptide and Anti-Hypertensive Peptide

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021; 27 (3)

Peptide drugs are generally compounds with 2-50 amino acids connected by peptide bonds and having drug effects. Because of their unique advantages suc......

l-Carnosine and Taurine Supplementation Attenuates the Intensity of Diabetes in Alloxan-Induced Diabetic Male Albino Rats

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021; 27 (3)

Diabetes is a metabolic disorder caused by defects in insulin production and insulin activity. l-Carnosine is a dipeptide containing histidine and bet......

A Novel Design of Multi-epitope Vaccine Against Helicobacter pylori by Immunoinformatics Approach

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, ; ()

Helicobacter pylori (H. pylori) is a gram-negative spiral bacterium that caused infections in half of the world's population and had been identified a......

Wound Healing Activity of Phage-Sisplayed TGF-beta 1 Model Peptide in Streptozotocin-Induced Diabetic Rats

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, ; ()

Objective To evaluate the effect of phage-displayed TGF-beta 1 model peptide on cutaneous wound healing in streptozotocin-induced diabetic rats. Metho......

Decreased Plasma Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Levels are Linked with Disease Severity in Patients with Liver Cirrhosis

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, ; ()

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide that has been found to reduce liver inflammation and protect liver from s......

Rational Design of Peptide Inhibitor Against Amyloidogenesis-Correlated Membrane Disruption by Merozoite Surface Protein 2

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, ; ()

New drugs and vaccines are urgently needed for malaria control owing to the increasing prevalence of drug-resistant Plasmodium strains. Malarial meroz......

GLP-1 Receptor Agonist Inhibited the Activation of RIPK1 for Alleviation the Neuronal Death and Neuroinflammation in APP/PS1 Mice

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, ; ()

Alzheimer's disease (AD) is characterized by neuronal necroptosis and neuroinflammation, retardation of these pathological development was considered ......

Response Surface Optimization of Enzymatic Hydrolysis of Peptides of Chinese Pecan (Carya cathayensis) and Analysis of Their Antioxidant Capacities and Structures

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, ; ()

Pecan cake, a by-product of pecan processing, has not been fully developed and utilized. It contains proteins with high nutritional value that can be ......

Substrate-Based Design of Human Farnesyltransferase Peptide-like Pain Antagonists

期刊: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, ; ()

Human protein farnesyltransferase is a key enzyme for the lipid modification of a large and important number of proteins, which has been recognized as......

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