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Identification of four novel prognosis biomarkers and potential therapeutic drugs for human colorectal cancer by bioinformatics analysis

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (1)

Colorectal cancer (CRC) is one of the most deadly cancers in the world with few reliable biomarkers that have been selected into clinical guidelines f......

A wearable real-time telemonitoring electrocardiogram device compared with traditional Holter monitoring

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (3)

Arrhythmias are very common in the healthy populations as well as patients with cardiovascular diseases. Among them, atrial fibrillation (AF) and mali......

The testis-specifically expressed gene Trim69 is not essential for fertility in mice

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (1)

Protein ubiquitination is essential for diverse cellular functions including spermatogenesis. The tripartite motif (TRIM) family proteins, most of whi......

Triclosan inhibits the activation of human periodontal ligament fibroblasts induced by lipopolysaccharide from Porphyromonas gingivalis

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (3)

Periodontitis is a highly prevalent, chronic, non-specific, and immunologically devastating disease of periodontal tissues, caused by microbial infect......

Correlation between radiologic features on contrast-enhanced CT and pathological tumor grades in pancreatic neuroendocrine neoplasms

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (3)

Contrast-enhanced computed tomography (CT) contributes to the increasing detection of pancreatic neuroendocrine neoplasms (PNENs). Nevertheless, its v......

Fucoidan antagonizes diet-induced obesity and inflammation in mice

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (3)

Obesity is an escalating global pandemic posing a serious threat to human health. The intervention therapy using weight-reducing drugs, accompanied by......

Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy - a pilot longitudinal study

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (1)

To evaluate if valproic acid (VPA) therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy, a cross-sectional clinica......

A comparative genomics analysis of lung adenocarcinoma for Chinese population by using panel of recurrent mutations

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (1)

Previous studies have demonstrated that Chinese lung adenocarcinoma (LUAD) patients have unique genetic characteristics, however, the specific genomic......

SARS-CoV-2 encoded microRNAs are involved in the process of virus infection and host immune response

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (3)

The outbreak of COVID-19 caused by SARS-CoV-2 is spreading worldwide, with the pathogenesis mostly unclear. Both virus and host-derived microRNA (miRN......

nNOS-mediated protein-protein interactions: promising targets for treating neurological and neuropsychiatric disorders

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (1)

Neurological and neuropsychiatric disorders are one of the leading causes of disability worldwide and affect the health of billions of people. Nitric ......

Insulin receptor is implicated in triple-negative breast cancer by decreasing cell mobility

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (3)

Triple-negative breast cancer (TNBC) has a poor prognosis and typically earlier onset of metastasis in comparison with other breast cancer subtypes. I......

alpha-ketoglutarate promotes the specialization of primordial germ cell-like cells through regulating epigenetic reprogramming

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2021; 35 (1)

There is growing evidence that cellular metabolism can directly participate in epigenetic dynamics and consequently modulate gene expression. However,......

RNA binding protein BOULE forms aggregates in mammalian testis

期刊: JOURNAL OF BIOMEDICAL RESEARCH, 2022; 36 (4)

Amyloids have traditionally been considered pathologic protein aggregates which contribute to neurodegeneration. New evidence however increasingly sug......

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