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Cartilage oligomeric matrix protein fine-tunes disturbed flow-induced endothelial activation and atherogenesis

期刊: MATRIX BIOLOGY, 2021; 95 ()

Disturbed flow leads to increased inflammatory responses of endothelial cells (ECs) prone to atherogenic state. Currently, little is known about the p......

Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis

期刊: MATRIX BIOLOGY, 2021; 95 ()

The tumor microenvironment encompasses a complex cellular network that includes cancer-associated fibroblasts, inflammatory cells, neo-vessels, and an......

Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection

期刊: MATRIX BIOLOGY, 2021; 96 ()

A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbellifer......

Significance of host heparanase in promoting tumor growth and metastasis

期刊: MATRIX BIOLOGY, 2020; 93 ()

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, angiogenesis and m......

The laminin binding alpha 3 and alpha 6 integrins cooperate to promote epithelial cell adhesion and growth

期刊: MATRIX BIOLOGY, 2019; 77 ()

Integrins, the major receptors for cell-extracellular matrix (ECM) interactions, regulate multiple cell biological processes including adhesion, migra......

JIF:6.99

Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy

期刊: MATRIX BIOLOGY, 2018; 66 ()

Periostin (Postn) is a crucial extracellular remodeling factor that has been implicated in the pathogenesis of hepatic inflammation, fibrosis, non-alc......

JIF:6.99

Extracellular matrix remodeling and cardiac fibrosis

期刊: MATRIX BIOLOGY, 2018; 68-69 ()

Cardiac fibrosis, characterized by excessive deposition of extracellular matrix (ECM) proteins in the myocardium, distorts the architecture of the myo......

JIF:6.99

Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events

期刊: MATRIX BIOLOGY, 2018; 70 ()

Intervertebral disc degeneration (IDD) causes back pain and sciatica, affecting quality of life and resulting in high economic/social burden. The etio......

JIF:6.99

Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction

期刊: MATRIX BIOLOGY, 2022; 112 ()

Cardiac fibrosis is a common irreversible pathological feature of diverse heart disorders. Uncontrolled cardiac fibrosis contributes to maladaptive ca......

JIF:11.276

Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened

期刊: MATRIX BIOLOGY, 2022; 110 ()

Although recent lineage studies strongly support a chondrocyte-to-osteoblast differentiation continuum, the biological significance and molecular basi......

JIF:11.276

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