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Uterine natural killer cells and recurrent spontaneous abortion

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2021; 86 (2)

Recurrent spontaneous abortion (RSA), termed as two or more consecutive pregnancy loss is a great problem for some women of childbearing age. A large ......

A systemic review of intravenous immunoglobulin G treatment in women with recurrent implantation failures and recurrent pregnancy losses

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2021; 85 (4)

Over the last few decades, the advancement in reproductive technologies and protocols to improve embryo quality through culture techniques and genetic......

Circadian rhythm-associated Rev-erb alpha modulates polarization of decidual macrophage via the PI3K/Akt signaling pathway

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2021; 86 (3)

Problem: Circadian rhythms are involved not only in the repair and regeneration of the immune system, but may also be associated with regulation of in......

Transcriptomics-determined chemokine-cytokine pathway presents a common pathogenic mechanism in pregnancy loss and spontaneous preterm birth

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ; ()

Problem Various etiological factors, such as infection and inflammation, may induce the adverse outcomes of pregnancy of miscarriage, stillbirth, or p......

Pathogenesis of uteroplacental acute atherosis: An update on current research

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ; ()

Uteroplacental acute atherosis is a type of arterial vascular disease that affects the placenta during pregnancy and predominates in the maternal spir......

Association of circulating monocyte chemoattractant protein-1 levels with polycystic ovary syndrome: A meta-analysis

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ; ()

Problem Polycystic ovary syndrome (PCOS) is a common hormonal disorder that has a huge impact on the human infertility. Increased levels of various ci......

Decidual-derived RANKL facilitates macrophages accumulation and residence at the maternal-fetal interface in human early pregnancy

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ; ()

Problem: During the first trimester, the accumulation of macrophages, which is the second largest decidual leukocyte population (similar to 20%) at th......

The low cytotoxic activity of peripheral blood NK cells may relate to unexplained recurrent miscarriage

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ; ()

Problem Unexplained recurrent miscarriage (uRM) is defined as two or more spontaneous abortions prior to 20 weeks of gestation with unknown etiology. ......

Fertility factors affect the vaginal microbiome in women of reproductive age

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2020; 83 (4)

Problem For women of reproductive age, achieving a successful pregnancy requires both the normal functioning of reproductive endocrine and the health ......

Comparison of therapeutic interventions for recurrent pregnancy loss in association with antiphospholipid syndrome: A systematic review and network meta-analysis

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2020; 83 (4)

Antiphospholipid syndrome (APS) is one of the treatable causes for pregnant women with recurrent pregnancy loss (RPL). This review compares the effica......

The role of CXC chemokine ligand 16 in physiological and pathological pregnancies

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2020; 83 (4)

The survival and development of a semi-allogeneic fetus during pregnancy require the involvement of a series of cytokines and immune cells. Chemokines......

The optimal timing of immunotherapy may improve pregnancy outcome in women with unexplained recurrent pregnancy loss: A perspective follow-up study in northeastern China

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2020; 83 (4)

Problem To determine whether patients with unexplained recurrent pregnancy loss (URPL) can benefit from pre-conception immunotherapy or on the early p......

PD-1 and PD-L1 expression on T-cell subsets in women with unexplained recurrent pregnancy losses

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2020; 83 (5)

Problem Does programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) expression on the T-cell subsets such as T helper (Th) 1, Th17, and Treg cell......

SPRY4 regulates trophoblast proliferation and apoptosis via regulating IFN-gamma-induced STAT1 expression and activation in recurrent miscarriage

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2020; 83 (6)

Problem The dysregulation of trophoblast functions is one of the leading causes of recurrent miscarriage (RM), which frustrates 1%-5% of couples of ch......

Effect of antithyroid antibodies on women with recurrent miscarriage: A meta-analysis

期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2020; 83 (6)

Problem The effect of thyroid autoimmunity (TAI) on the prevalence of recurrent miscarriage (RM) is highly debatable. No meta-analysis has been publis......

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