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The reversible reproductive toxicity of 5-fluorouracil in mice

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 101 ()

5-Fluorouracil (5-FU) is a ?cytotoxic? drug used for cancer chemotherapy, which inhibits cells division via affecting DNA synthesis. Although being wi......

Cadmium triggers oxidative stress and mitochondrial injury mediated apoptosis in human extravillous trophoblast HTR-8/SVneo cells

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 101 ()

Cadmium (Cd) is a bioaccumulative heavy metal element with potential placental toxicity during pregnancy. Up to now, however, the precise toxic effect......

Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 104 ()

Accumulating studies have been focused on the independent effects of air pollutants and ambient heat exposure on congenital heart defects (CHDs) but w......

The role of lncRNA Meg3 in the proliferation of all-trans retinoic acid-treated mouse embryonic palate mesenchymal cells involves the Smad pathway

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 104 ()

Mesenchymal cell proliferation is critical for the growth of the palate shelf. All-trans retinoic acid (atRA), as well as pathways associated with TGF......

Determination of the panel of reference genes for quantitative real-time PCR in fetal and adult rat intestines

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 104 ()

In quantitative real-time PCR (qRT-PCR) detection, the stability of reference genes varies with different organs, tissue locations, sex and developmen......

Resveratrol ameliorates malathion-induced estrus cycle disorder through attenuating the ovarian tissue oxidative stress, autophagy and apoptosis

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 104 ()

Malathion is a high-efficiency organic phosphorus broad-spectrum insecticide which is commonly used in agricultural production, sanitation and epidemi......

Evaluation of post-adolescence exposure to bisphenol A on reproductive outcomes of male rodent models

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 101 ()

The effect of post-adolescence bisphenol A (BPA) exposure on the reproductive system is not well-defined. We therefore performed this meta-analysis to......

Decreased miR-149 expression in sperm is correlated with the quality of early embryonic development in conventional in vitro fertilization

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 101 ()

miRNAs play a critical role in the regulation of highly orchestrated gene expression profiles during spermatogenesis and early human embryonic develop......

Evaluation of atrazine neurodevelopment toxicity in vitro-application of hESC-based neural differentiation model

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 103 ()

Atrazine is one of the widely used herbicides in the world and most of the current researches on atrazine neurodevelopment toxicity have focused on ro......

No obviously adverse pregnancy complications and outcomes of the recovered pregnant women from COVID-19

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 100 ()

The effects of SARS-COV-2 infection on the pregnant women and their fetus growth have attracted worldwide concern. Our case study aimed to investigate......

Panel of suitable reference genes and its gender differences of fetal rat liver under physiological conditions and exposure to dexamethasone during pregnancy

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 100 ()

The panel of suitable reference genes in the fetal liver have not been reported. In this study, five commonly used reference genes (GAPDH, beta-actin,......

Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 100 ()

We have reported that smoking during pregnancy is associated with deficit in neonatal central chemoreception. However, the underlying mechanism is not......

Host microRNAs regulate expression of hepatitis B virus genes during transmission from patients & rsquo; sperm to embryo

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 100 ()

Human sperm nucleus contains diverse RNA populations. This study aimed to screen and identify host microRNAs (miRs) that regulate gene expression of h......

Recognized trophoblast-like cells conversion from human embryonic stem cells by BMP4 based on convolutional neural network

期刊： REPRODUCTIVE TOXICOLOGY, 2021; 99 ()

The use of models of stem cell differentiation to trophoblastic cells provides an effective perspective for understanding the early molecular events i......

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